Extracellular sulfatase Sulf-2

BE0016611ProteinHumansSULF2

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It is acted on by 2 drugs in DrugBank.

Gene name
SULF2
UniProtKB entry
Q8IWU5Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
870 residues · 100,454 Da
Also known as
Arylsulfatase · hSulf-2 · KIAA1247 · N-acetylglucosamine-6-sulfatase

Resolves to

Protein
UniProtQ8IWU5UniProt nameSULF2_HUMAN
Gene
HGNCHGNC:20392NCBI Gene55959GeneCardsSULF2
Pharmacology
KEGGhsa:55959
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Extracellular sulfatase Sulf-2, how selective are they, and which programs against it are still in active trials?

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