Phosphatidylcholine:ceramide cholinephosphotransferase 2

BE0017188ProteinHumansSGMS2

Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. It is acted on by 2 drugs in DrugBank.

Gene name
SGMS2
UniProtKB entry
Q8NHU3Swiss-Prot
Cellular location
Cell membrane
Residues / weight
365 residues · 42,280 Da
Also known as
2.7.8.27 · SMS2 · Sphingomyelin synthase 2

Resolves to

Protein
UniProtQ8NHU3UniProt nameSMS2_HUMAN
Gene
HGNCHGNC:28395NCBI Gene166929GeneCardsSGMS2
Pharmacology
IUPHAR/GtoPdb2521KEGGhsa:166929
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphatidylcholine:ceramide cholinephosphotransferase 2, and which indications are they being tested in?

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