Lysophosphatidic acid receptor 1

Details

Name
Lysophosphatidic acid receptor 1
Kind
protein
Synonyms
  • EDG2
  • LPA receptor 1
  • LPA-1
  • LPA1
  • Lysophosphatidic acid receptor Edg-2
Gene Name
LPAR1
UniProtKB Entry
Q92633Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0060506|Lysophosphatidic acid receptor 1
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
Number of residues
364
Molecular Weight
41108.965
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity)
Specific Function
G protein-coupled receptor activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
51-75 84-107 122-144 164-184 205-225 256-280 295-315
Cellular Location
Cell surface
Gene sequence
Not Available
Chromosome Location
9
Locus
9q31.3
External Identifiers
ResourceLink
UniProtKB IDQ92633
UniProtKB Entry NameLPAR1_HUMAN
GeneCard IDLPAR1
HGNC IDHGNC:3166
PDB ID(s)4Z34, 4Z35, 4Z36, 7TD0, 7TD1, 7TD2, 7YU3, 7YU4, 7YU5, 7YU6, 7YU7, 7YU8
KEGG IDhsa:1902
IUPHAR/Guide To Pharmacology ID272
NCBI Gene ID1902
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
BMS-986020investigationalyestargetantagonistDetails
FipaxalparantinvestigationalyestargetmodulatorDetails
BMS-986278investigationalyestargetantagonistDetails