Carotenoid-cleaving dioxygenase, mitochondrial

BE0019198ProteinHumansBCO2

Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. It is acted on by 3 drugs in DrugBank.

Gene name
BCO2
UniProtKB entry
Q9BYV7Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
579 residues · 65,674 Da
Also known as
1.13.11.- · 1.13.11.71 · B-diox-II · BCDO2 · Beta-carotene dioxygenase 2

Resolves to

Protein
UniProtQ9BYV7UniProt nameBCDO2_HUMAN
Gene
HGNCHGNC:18503NCBI Gene83875GeneCardsBCO2
Pharmacology
KEGGhsa:83875
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carotenoid-cleaving dioxygenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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