Zeaxanthin
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Zeaxanthin
- DrugBank Accession Number
- DB11176
- Background
Zeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some micro-organisms. It gives the distinct yellow color to many vegetables and other plants including paprika, corn, saffron and wolfberries. Zeaxanthin is one of the two primary xanthophyll carotenoids contained within the retina of the eye and plays a predominant component in the central macula. It is available as a dietary supplement for eye health benefits and potential prevention of age-related macular degeneration. Zeaxanthin is also added as a food dye.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 568.886
Monoisotopic: 568.428031043 - Chemical Formula
- C40H56O2
- Synonyms
- Not Available
- External IDs
- E 161H
- E-161H(I)
- INS NO.161H(I)
- INS-161H(I)
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Take with or without food.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image BiO-LiFE Bio-Vizion Soft Capsules Zeaxanthin (320 mcg) + Ascorbic acid (60 mg) + Beta carotene (3 mg) + Lutein (6 mg) + Selenomethionine (26 mcg) + Vitamin E (50 IU) + Zinc oxide (10 mg) Capsule Oral BIO-LIFE MARKETING SDN. BHD. 2016-02-25 2020-01-23 Malaysia GNC Multivitamin Mega Women Tablet Zeaxanthin (200 mcg) + Ascorbic acid (100 mg) + Astaxanthin (25 mcg) + Biotin (150 mcg) + Boron (1 mg) + Calcium (250 mg) + Cholecalciferol (800 IU) + Choline (5 mg) + Chromium (60 mcg) + Copper (1 mg) + Cryptoxanthin (5 mcg) + Cyanocobalamin (25 mcg) + Folic acid (200 mcg) + Grape seed oil (0.5 mg) + Green tea leaf (7 mg) + Hyaluronic acid (0.5 mg) + Inositol (5 mg) + Iodine (75 mcg) + Iron (9 mg) + Lipoic acid (12.5 mg) + Lutein (1 mg) + Lycopene (0.5 mg) + Magnesium (25 mg) + Manganese cation (1 mg) + Molybdenum (37.5 mcg) + Niacin (25 mg) + Pantothenic acid (25 mg) + Phylloquinone (40 mcg) + Pyridoxine (25 mg) + Riboflavin (25 mg) + Selenium (100 mcg) + Silicon dioxide (2 mg) + Thiamine (25 mg) + Turmeric (250 mcg) + Vanadium (5 mcg) + Vitamin A (2500 IU) + Vitamin E (15 IU) + Zinc (7.5 mg) + gamma-Aminobutyric acid (0.5 mg) Tablet Oral GNC LIVEWELL MALAYSIA SDN. BHD. 2020-09-08 Not applicable Malaysia GNC NATURAL BRAND LUTEIN PLUS Zeaxanthin (2 mg) + Lutein (40 mg) Capsule Oral GNC LIVEWELL MALAYSIA SDN. BHD. 2020-09-08 Not applicable Malaysia Vista Advanced AREDS2 Formula Zeaxanthin (1 mg/966.47mg) + Ascorbic acid (250 mg/966.47mg) + Copper gluconate (1 mg/966.47mg) + Glutathione (25 mg/966.47mg) + Lutein (5 mg/966.47mg) + Selenium (0.0275 mg/966.47mg) + Vitamin E (137.5 mg/966.47mg) Capsule Oral Red Wedding LLC 2020-09-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Macuvex Zeaxanthin (1 mg/1) + Ascorbic acid (250 mg/1) + Copper (1 mg/1) + Folic acid (1 mg/1) + Lutein (5 mg/1) + Zinc oxide (40 mg/1) + alpha-Tocopherol acetate (200 [iU]/1) Capsule Oral Sterling-knight Pharmaceuticals,LLC 2014-11-16 2015-07-28 US Macuzin Zeaxanthin (2 mg/1) + Ascorbic acid (500 mg/1) + Copper (2 mg/1) + DL-alpha tocopheryl acetate (400 [iU]/1) + Folic acid (1 mg/1) + Lutein (10 mg/1) + Zinc oxide (80 mg/1) Capsule Oral Sterling-Knight Pharmaceuticals, LLC 2015-04-30 2018-07-30 US Ocuvel Zeaxanthin (2 mg/1) + Ascorbic acid (500 mg/1) + Copper (2 mg/1) + Folic acid (1 mg/1) + Lutein (10 mg/1) + Zinc oxide (80 mg/1) + alpha-Tocopherol acetate (400 [iU]/1) Capsule Oral Adler-Stern Pharmaceuticals, LLC 2014-11-05 Not applicable US Ocuvel Zeaxanthin (1 mg/1) + Ascorbic acid (250 mg/1) + Copper (1 mg/1) + Folic acid (0.5 mg/1) + Lutein (5 mg/1) + Zinc oxide (40 mg/1) + alpha-Tocopherol acetate (200 [iU]/1) Capsule Oral Adler-Stern Pharmaceuticals, LLC 2014-12-01 Not applicable US Tozal Zeaxanthin (3 mg/31) + Ascorbic acid (452 mg/31) + Cholecalciferol (1000 [iU]/31) + Copper (1.6 mg/31) + Cyanocobalamin (100 ug/31) + Folic acid (1 mg/31) + Lutein (15 mg/31) + Omega-3 fatty acids (600 mg/31) + Pyridoxine hydrochloride (20 mg/31) + Taurine (400 mg/31) + Vitamin A palmitate (10000 [iU]/31) + Vitamin E (200 [iU]/31) + Zinc picolinate (40 mg/31) Capsule, gelatin coated Oral Focus Laboratories, Inc. 2013-06-01 2015-07-15 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as xanthophylls. These are carotenoids containing an oxygenated carotene backbone. Carotenes are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Xanthophylls arise by oxygenation of the carotene backbone.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Prenol lipids
- Sub Class
- Tetraterpenoids
- Direct Parent
- Xanthophylls
- Alternative Parents
- Secondary alcohols / Hydrocarbon derivatives
- Substituents
- Alcohol / Aliphatic homomonocyclic compound / Hydrocarbon derivative / Organic oxygen compound / Organooxygen compound / Secondary alcohol / Xanthophyll
- Molecular Framework
- Aliphatic homomonocyclic compounds
- External Descriptors
- carotenol (CHEBI:27547) / C40 isoprenoids (tetraterpenes), Carotenoids (C06098) / C40 isoprenoids (tetraterpenes) (LMPR01070261)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- CV0IB81ORO
- CAS number
- 144-68-3
- InChI Key
- JKQXZKUSFCKOGQ-QAYBQHTQSA-N
- InChI
- InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-24,35-36,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36-/m1/s1
- IUPAC Name
- (1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]-3,5,5-trimethylcyclohex-3-en-1-ol
- SMILES
- C\C(\C=C\C=C(/C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)C[C@@H](O)CC1(C)C
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0002789
- KEGG Compound
- C06098
- PubChem Compound
- 5280899
- PubChem Substance
- 347827933
- ChemSpider
- 4444421
- 39918
- ChEBI
- 27547
- ChEMBL
- CHEMBL2359248
- ZINC
- ZINC000008220175
- PDBe Ligand
- 5X6
- Wikipedia
- Zeaxanthin
- PDB Entries
- 8wey
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data3 Completed Treatment Age - Related Macular Degeneration (AMD) / Cataracts 1 somestatus stop reason just information to hide 2 Completed Prevention Nutrient Deficiency / Pregnancy Related 1 somestatus stop reason just information to hide 2 Completed Treatment NPDR - Non Proliferative Diabetic Retinopathy / Type 2 Diabetes Mellitus 1 somestatus stop reason just information to hide 1 Recruiting Treatment Metastatic Cancer / Metastatic Solid Neoplasm 1 somestatus stop reason just information to hide 1, 2 Terminated Other Glaucoma 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Capsule, gelatin coated Oral Tablet Oral Capsule, liquid filled Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000649 mg/mL ALOGPS logP 8.3 ALOGPS logP 8.35 Chemaxon logS -5.9 ALOGPS pKa (Strongest Acidic) 18.91 Chemaxon pKa (Strongest Basic) -0.79 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 40.46 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 194.95 m3·mol-1 Chemaxon Polarizability 73.47 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 324.8593396 predictedDarkChem Lite v0.1.0 [M-H]- 324.1645396 predictedDarkChem Lite v0.1.0 [M-H]- 324.0957396 predictedDarkChem Lite v0.1.0 [M-H]- 261.269 predictedDeepCCS 1.0 (2019) [M+H]+ 326.5805396 predictedDarkChem Lite v0.1.0 [M+H]+ 329.7005396 predictedDarkChem Lite v0.1.0 [M+H]+ 329.5139396 predictedDarkChem Lite v0.1.0 [M+H]+ 263.16443 predictedDeepCCS 1.0 (2019) [M+Na]+ 324.7397396 predictedDarkChem Lite v0.1.0 [M+Na]+ 326.3775396 predictedDarkChem Lite v0.1.0 [M+Na]+ 324.7563396 predictedDarkChem Lite v0.1.0 [M+Na]+ 269.07205 predictedDeepCCS 1.0 (2019)
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53