Protein-serine O-palmitoleoyltransferase porcupine

BE0019221ProteinHumansPORCN

Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. It is acted on by 3 drugs in DrugBank.

Gene name
PORCN
UniProtKB entry
Q9H237Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
461 residues · 52,317 Da
Also known as
2.3.1.250 · MG61 · PORC · PPN · Protein MG61

Resolves to

Protein
UniProtQ9H237UniProt namePORCN_HUMAN
Gene
HGNCHGNC:17652NCBI Gene64840GeneCardsPORCN
Pharmacology
IUPHAR/GtoPdb3145KEGGhsa:64840
Structure
PDB7URAPDB7URCPDB7URD
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein-serine O-palmitoleoyltransferase porcupine, and which indications are they being tested in?

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