WNT-974

DB12561InvestigationalSmall molecule

WNT974 has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.

Mechanism: Pharmacologically active on Protein-serine O-palmitoleoyltransferase porcupine
Curator reviewed
Formula / weight: C₂₃H₂₀N₆O · 396.454 g/mol (avg)
Also known as: (2,4'-bipyridine)-5-acetamide, 2',3-dimethyl-N-(5-(2-pyrazinyl)-2-pyridinyl)-
Code names: LGK-974 · NVP-LGK974 · WNT 974

Resolves to

Compound

Structure

InChIKeyXXYGTCZJJLTAGH-UHFFFAOYSA-NSMILESCC1=CC(=CC=N1)C1=NC=C(CC(=O)NC2=CC=C(C=N2)C2=CN=CC=N2)C=C1C

Targets

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with WNT-974, and which of those have an active Phase 3 trial?

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