rRNA methyltransferase 2, mitochondrial

BE0020789ProteinHumansMRM2

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU... It is acted on by 1 drug in DrugBank.

Gene name
MRM2
UniProtKB entry
Q9UI43Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
246 residues · 27,423 Da
Also known as
16S rRNA (uridine(1369)-2'-O)-methyltransferase · 16S rRNA [Um1369] 2'-O-methyltransferase · 2.1.1.- · FJH1 · FTSJ2

Resolves to

Protein
UniProtQ9UI43UniProt nameMRM2_HUMAN
Gene
HGNCHGNC:16352NCBI Gene29960GeneCardsMRM2
Pharmacology
KEGGhsa:29960
Structure
PDB2NYUPDB7O9KPDB7O9M
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on rRNA methyltransferase 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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