Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

BE0021454ProteinHumansHCN4

Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353). It is acted on by 5 drugs in DrugBank.

Gene name
HCN4
UniProtKB entry
Q9Y3Q4Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,203 residues · 129,041 Da

Resolves to

Protein
UniProtQ9Y3Q4UniProt nameHCN4_HUMAN
Gene
HGNCHGNC:16882NCBI Gene10021GeneCardsHCN4
Pharmacology
IUPHAR/GtoPdb403KEGGhsa:10021
Structure
PDB2MNGPDB3OTFPDB3U11
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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29GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, how selective are they, and which programs against it are still in active trials?

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