Metalloendopeptidases

Name
Metalloendopeptidases
Accession Number
DBCAT000140
Description

ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.

Drugs
DrugDrug Description
Botulinum toxin type BA purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.
Collagenase clostridium histolyticumA collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers as well as to treat Dupuytren's contracture and Peyronie's disease.
Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
PraconaseInvestigated for use/treatment in spinal cord injuries.
Botulinum toxin type FNot Annotated
Apadamtase alfaA recombinant human ADAMTS13 for enzyme replacement therapy in patients with congenital thrombotic thrombocytopenic purpura.
Microbial collagenaseNot Annotated
Botulinum Toxin Type EBotulinum toxin type e is under investigation in clinical trial NCT03193593 (Study to Evaluate EB-001 in Reducing Musculoskeletal Pain).
Drugs & Drug Targets
DrugTargetType
Botulinum toxin type BVesicle-associated membrane protein 1target
Botulinum toxin type BVesicle-associated membrane protein 2target
Botulinum toxin type BSynaptotagmin-2target
Collagenase clostridium histolyticumCollagen alpha-1(I) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(II) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(III) chaintarget
Botulinum toxin type ASynaptosomal-associated protein 25target
Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
Botulinum toxin type AAlbumincarrier
Apadamtase alfavon Willebrand factortarget