Metalloproteases

DBCAT000141Pharmacologic class

Proteases which use a metal, normally ZINC, in the catalytic mechanism. This group of enzymes is inactivated by metal CHELATORS. A DrugBank category of 10 drugs. 6 of them are approved.

Also known as: Metallopeptidases · Metalloproteinases
Drugs: Alfimeprase
Apadamtase alfa
Botulinum toxin type A
Botulinum toxin type B
Botulinum toxin type F
Collagenase clostridium histolyticum
LetibotulinumtoxinA
Microbial collagenase
Praconase
TrenibotulinumtoxinE

What you can answer from here — as of August 24, 2016

10DrugsEach linked to its full drug card

Listed above

13Drug targetsEvery drug–target pair in the class, with bond type

149Marketed productsAcross the regions we cover, with dosage forms and routes

9Routes of administrationHow the drugs in this class are given

Which targets do Metalloproteases share, and which companies have late-stage candidates in this class?

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