- Amino Acids
- Accession Number
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
- ATC Classification
Drug Drug Description Arginine An amino acid commonly found as a component of total parenteral nutrition. Aminocaproic acid An antifibrinolytic agent used to induce clotting postoperatively. L-Glutamine An amino acid commonly found as a component in total parenteral nutrition. Histidine An amino acid commonly found as a component of total parenteral nutrition. Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Phenylalanine An amino acid commonly found as a component of total parenteral nutrition. Aspartic acid An amino acid commonly found as a component in total parenteral nutrition. Serine An amino acid commonly found as a component in total parenteral nutrition. Methionine An amino acid commonly found as a component in total parenteral nutrition. Tyrosine An amino acid commonly found as a component in total parenteral nutrition. Glutamic acid An amino acid commonly found as a component in total parenteral nutrition. Glycine An amino acid commonly used as a component of total parenteral nutrition and is also used as irrigation during surgery. Creatine For nutritional supplementation, also for treating dietary shortage or imbalance. Leucine An amino acid commonly found as a component of total parenteral nutrition. Tryptophan An amino acid commonly found as a component of total parenteral nutrition. Cysteine An amino acid commonly found as a component of total parenteral nutrition and used as an antidote for acetaminophen overdose. Citrulline Used for nutritional supplementation, also for treating dietary shortage or imbalance. Threonine An amino acid commonly found as a component of total parenteral nutrition. Alanine An amino acid commonly found as a component of total parenteral nutrition. Valine An amino acid commonly found as a component of total parenteral nutrition. Isoleucine An amino acid commonly found as a component of total parenteral nutrition. Proline An amino acid commonly found as a component of total parenteral nutrition. Asparagine Used for nutritional supplementation, also for treating dietary shortage or imbalance. Baclofen A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Cycloserine A broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI). Levothyroxine A synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. Dextrothyroxine A thyroid hormone used to treat hyperlipidemia. Valaciclovir An guanine nucleoside antiviral used to treat herpes exacerbations. Pemetrexed A folate analog used to treat mesothelioma and non-small cell lung cancer. Metyrosine A tyrosine 3-monooxygenase inhibitor used to treat excessive sympathetic stimulation in pheochromocytoma. Tirofiban A platelet aggregation inhibitor used to prevent thrombotic events in non-ST elevated acute coronary syndrome. Aminolevulinic acid A porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma. Penicillamine A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Melphalan An alkylating agent used to treat multiple myeloma, ovarian carcinoma, uveal melanoma with unresectable hepatic metastases, and for high-dose conditioning before hematopoietic stem cell transplant in patients. Mimosine Mimosine is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca. Captopril An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. Levodopa A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Stepronin Strepronin is a mucolytic (expectorant) drug. Liotrix May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic... N-Acetylmethionine An amino acid used as a peritoneal dialysis treatment in patients with renal failure and nutritional therapy in patients with nutritional deficiency or post-infection weakness. Pantothenic acid A vitamin B5 found in various nutritional supplements. N,N-dimethylglycine Not Available S-Methylcysteine Not Available L-methionine (R)-S-oxide Not Available Selenocysteine A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and... Leucine Phosphonic Acid Not Available N-Acetylalanine Not Available Pyrrole-2-Carboxylate Not Available 4-Hydroxyphenylglycine Not Available D-Aspartic Acid The D-isomer of aspartic acid. [PubChem] Canaline Not Available 2-aminoisobutyric acid Not Available Oxitriptan A naturally occurring amino acid that is used to manage post-hypoxic myoclonus. Beta-Hydroxyleucine Not Available Quisqualic acid Quisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular... Pidolic acid There is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in... beta-Alanine beta-Alanine is an amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may... N,O-didansyl-L-tyrosine Not Available Vinylglycine Vinylglycine is an irreversible inhibitor of aspartate aminotransferase. Diphthamide Not Available N-Acetylproline Not Available L-tyrosinamide Not Available Ubenimex An adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia. 2s,4r-4-Methylglutamate Not Available N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acid N(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. Sparfosic acid Sparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen... S-Phosphocysteine Not Available 3-Tyrosine Not Available Beta-Hydroxyaspartic Acid Not Available 4-Iodo-L-phenylalanine Not Available Trifluoromethionine Not Available L-2,4-diaminobutyric acid Not Available Oxamic Acid Amino-substituted glyoxylic acid derivative. [PubChem] Phenylalanylamide Not Available Norvaline A drug used to treat vaginal inflammation with betamethasone and tyrothricin. L-2-amino-3-butynoic acid Not Available L-proline betaine Not Available Oxfenicine Oxfenicine in an inhibitor of myocardial metabolism of nonesterified fatty acids (NEFA). D-4-hydroxyphenylglycine Not Available 6-hydroxydopa quinone Not Available S-sulphocysteine Not Available Adenylosuccinic acid Not Available Alpha-Aminobutyric Acid Not Available N-Formylmethionine N-Formylmethionine is effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well... Aspartate Semialdehyde Not Available Glyphosate Not Available Phenyldehydroalanine Not Available Cycloleucine Cycloleucine is non-metabolisable amino acid formed by cyclization of leucine. It is also a specific and reversible inhibitor of nucleic acid methylation and widely used in biochemical experiments. THIO-ATPA Not Available Roxadustat A hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to treat symptomatic anemia associated with chronic kidney disease. CDP323 Investigated for use/treatment in multiple sclerosis. LX1031 Irritable bowel syndrome (IBS) and other gastrointestinal disorders Alanosine Investigated for use/treatment in brain cancer and cancer/tumors (unspecified). Acetylcysteine A medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose. Hexaminolevulinate An optical imaging agent used to perform Blue Light Cystoscopy (BLC™) in order to detect carcinoma of the bladder. Droxidopa A medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease. GW-559090 Investigated for use/treatment in asthma and allergic rhinitis. Etilevodopa Investigated for use/treatment in parkinson's disease. Carglumic acid An analog of N-acetylglutamate (NAG) used for the treatment of acute and chronic hyperammonemia in patients with N-acetylglutamate synthase (NAGS) deficiency. Lodoxamide An ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis. N-BENZOYL-D-ALANINE Not Available Thiorphan A potent inhibitor of membrane metalloendopeptidase (enkephalinase). Thiorphan potentiates morphine-induced analgesia and attenuates naloxone-precipitated withdrawal symptoms. Hydroxyproline Used in France as a combination product for the treatment of small, superficial wounds. Technetium Tc-99m disofenin A radiopharmaceutical diagnostic agent used for hepatobiliary scans. N-acetyltyrosine An amino acid used in total parenteral nutrition. Selenomethionine Selenomethionine is a naturally occuring amino acid in some plant materials such as cereal grains, soybeans and enriched yeast but it cannot be synthesized from animals or humans. It can... Oxothiazolidinecarboxylic acid Procysteine has been used in trials studying the treatment of HIV Infections. Theanine Theanine, a precursor of ethylamine, is found in green tea. It is under investigation in clinical trial NCT00291070 (Effects of L-Theanine in Boys With ADHD). Sarcosine Sarcosine has been investigated for the treatment of Schizophrenia. Methylselenocysteine Methylselenocysteine has been used in trials studying the prevention of Prostate Carcinoma and No Evidence of Disease. Indoximod Indoximod has been used in trials studying the treatment of Glioma, Melanoma, Ependymoma, Gliosarcoma, and Lung Cancer, among others. Buthionine sulfoximine Buthionine sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin). AV-101 AV-101 has been used in trials studying the treatment of Neuropathic Pain. Racemethionine A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers. Tranexamic acid An antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. Alanyl glutamine A dipeptide consisting of alanine and glutamine used for supplementation. Aminomethylbenzoic acid Aminomethylbenzoic acid may be useful as an antifibrinolytic agent . Ornithine An amino acid commonly found as a component in total parenteral nutrition. Remdesivir A nucleoside analog used to treat RNA virus infections including COVID-19. Amino acids Mixture of amino acids ; used for parenteral nutrition in infants. Fluorodopa (18F) Fluorodopa F 18 is indicated for use with positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adult patients with suspected Parkinsonian syndromes... Ivosidenib An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation. Solriamfetol Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744]. Canavanine Not Available Kynurenine Not Available Allysine Not Available Carbocisteine A expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity. Racemetyrosine Racemetyrosine is under investigation in clinical trial NCT03512756 (A Randomized Phase 2/3 Multi-center Study of SM-88 in Patients With Metastatic Pancreatic Cancer). Melphalan flufenamide A melphalan prodrug used to treat relapsed or refractory multiple myeloma. Lysine An amino acid commonly found as a component of total parenteral nutrition. Taurine An ingredient found in mixture products indicated for nutritional support. D-Glutamine A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of... 2,6-Diaminopimelic Acid Not Available Sacubitril A neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Methyl aminolevulinate A porphyrin precursor used to treat non-hyperkeratotic, non-pigmented actinic keratosis of the face and scalp. N-(Phosphonoacetyl)-L-Ornithine Not Available Hadacidin Not Available Glycinamide Ribonucleotide Not Available Glycocyamine Not Available N(G)-Iminoethylornithine Not Available 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available N-hexadecanoylglycine Not Available Glycinamide Not Available Bicine Not Available Willardiine Willardiine is a compound isolated from seeds of Acacia willariana. INCB3284 Investigated for use/treatment in inflammatory disorders (unspecified). Managlinat dialanetil Investigated for use/treatment in diabetes mellitus type 2. LY-517717 Investigated for use/treatment in thrombosis and venous thromboembolism. SNX-5422 Investigated for use/treatment in cancer/tumors (unspecified). Talotrexin Investigated for use/treatment in solid tumors, lung cancer, leukemia (unspecified), and leukemia (lymphoid). Eflornithine A medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin. Muraglitazar Investigated for use/treatment in diabetes mellitus type 2. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Valrocemide Investigated for use/treatment in epilepsy. Z-Val-Ala-Asp fluoromethyl ketone Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the... Technetium Tc-99m mebrofenin A diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests. Tenofovir alafenamide A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease. Ixazomib A monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already. Ferrous bisglycinate Ferrous bisglycinate is a chelate that is used as a source of dietary iron. Forming a ring structure when reacting with glycine, ferrous bisglycinate acts as both a chelate and... Cupric glycinate Not Annotated Rebamipide A gastroprotective agent used in combination with other similar therapies (e.g. proton pump inhibitors) to treat gastritis and protect the gastric mucosa. Daprodustat A small-molecule hypoxia-inducible factor prolyl hydroxylase inhibitor used for the treatment of anemia in patients with chronic kidney disease. Tosedostat Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others. Tosedostat is an inhibitor of the... Faldaprevir Faldaprevir has been investigated for the treatment of Chronic Hepatitis C. Brivanib alaninate Brivanib alaninate has been investigated for the treatment of Colorectal Cancer. Brivanib Brivanib is under investigation for the treatment of HepatoCellular Carcinoma. Brivanib has been investigated for the treatment of Solid Tumors, Hepato Cellular Carcinoma (HCC), and Metastatic Colorectal Cancer (MCRC). Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Rigosertib Rigosertib has been used in trials studying the treatment and basic science of MDS, RAEB, Cancer, Hepatoma, and Neoplasms, among others. Vadadustat An oral hypoxia-inducible factor prolyl-hydroxylase inhibitor used to treat symptomatic anemia associated with chronic kidney disease in adults on chronic maintenance dialysis. Semagacestat Semagacestat has been used in trials studying the treatment of Alzheimer Disease. Indantadol Indantadol has been used in trials studying the treatment of Cough and Diabetic Peripheral Neuropathic Pain. Rabacfosadine Rabacfosadine has been used in trials studying the treatment of Multiple Myeloma, Non-Hodgkin's Lymphoma, and Chronic Lymphocytic Leukemia. Sivelestat Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult. Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... Prethcamide Not Annotated Aluminium glycinate A medication indicated to treat heartburn, indigestion, acid reflux, ulcers, and gas. Camylofin Not Annotated Glecaprevir A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. Sacubitrilat A metabolite of LCZ696 with neprilysin inhibitory activity. Zinc glycinate Glycoprotein marker of gastrointestinal cancer. Adafosbuvir Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335). GS-6620 GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection). Fasitibant Fasitibant is under investigation in clinical trial NCT02205814 (Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee). Mebrofenin Not Annotated DAPTA Not Annotated Cystine An oxidated derivative of the amino acid cysteine found in various nutritional products, acne treatments, and creams to treat cervical injury or inflammation. Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Promazine A phenothiazine used to manage schizophrenia. Fosinopril An ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics. Nateglinide A meglitinide used to treat non insulin dependent diabetes mellitus. Progabide Indicated for the treatment of epilepsy. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. N,N-dimethylarginine Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells which... Epsilon-N-methyllysine Not Available L-alloisoleucine Not Available Tetraiodothyroacetic acid Not Available S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. N-acetyl-L-arginine Not Available Epicaptopril Not Available Glycochenodeoxycholic Acid A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed.... 4-methylthio-2-oxobutanoic acid Not Available 5'-S-methyl-5'-thioadenosine Not Available Symmetric dimethylarginine Not Available Glutamine hydroxamate Not Available gamma-Aminobutyric acid The most common inhibitory neurotransmitter in the central nervous system. Glycocholic acid The glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed. N-(2-Acetamido)Iminodiacetic Acid Not Available Cysteine-S-acetamide Not Available Isoglutamine Not Available N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Not Available RWJ-51084 Not Available 5-fluorotryptophan 5-fluorotryptophan can be used as substrate analogue to study enzyme mechanisms by NMR spectroscopy. 6-hydroxynorleucine Not Available L-serine O-sulfate Not Available Tiratricol A metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome. L-cysteic acid L-cysteic acid is a beta-sulfoalanine. It is an amino acid with a C-terminal sulfonic acid group which has been isolated from human hair oxidized with permanganate. It occurs normally in... L-methionine sulfone Not Available 3-Methylglutamic acid Not Available gamma-carboxy-L-glutamic acid Not Available 3-nitro-L-tyrosine Not Available Batimastat Not Available 5-Oxoprolinal Not Available Thiocitrulline Not Available L-homoarginine Not Available Trimethyllysine Not Available 1-Methylhistidine Not Available Aceglutamide Not Available N(2)-(2-carboxyethyl)-L-arginine Not Available L-Saccharopine Not Available Nitroarginine An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in... N-Carbamoylaspartic acid An amino acid commonly found as a component in total parenteral nutrition. Homocysteine Homocysteine is a thiol-containing amino acid formed by a demethylation of methionine. Paratoulene phosphate Not Available Dexfosfoserine An amino acid used for nutritional supplementation therapy in over-fatigue states. beta-Hydroxyasparagine Not Available S-Benzylcysteine Not Available Tryptophanamide Not Available Dansyllysine Not Available Rupintrivir Investigated for use/treatment in viral infection. WX-UK1 Investigated for use/treatment in solid tumors. Palifosfamide Investigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma. BL-1020 Investigated for use/treatment in schizophrenia and schizoaffective disorders. PPI-2458 Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors. Trofinetide A drug used to treat Rett syndrome in children and adults. AB192 Investigated for use/treatment in diabetes mellitus type 2. Tiopronin A thiol agent indicated for the prevention of kidney stone formation in patients with severe homozygous cystinuria. methyl L-phenylalaninate Not Available p-Benzoyl-L-phenylalanine Not Available Zofenoprilat Not Available Gabapentin enacarbil A gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN). Boceprevir A hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Boceprevir is not indicated as monotherapy. Daclatasvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Clonixin An NSAID used to relieve pain associated with arthritis, migraines, and various soft tissue disorders. Azelnidipine For the treatment of hypertension. Eluxadoline A mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea. Ombitasvir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Paritaprevir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Dexpanthenol An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN). Selenomethionine Se-75 Not Annotated Panthenol An ingredient used in skin, hair care, and nutritional products but is not an approved medication. Levomefolic acid A folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. Pidotimod A synthetic agent with immunomodulatory properties used in patients with documented cell-mediated immunosuppression to stimulate their immunity during lung and urinary tract infections. Lifitegrast A medication used to treat dry eye disease. Racecadotril An anti-secretory enkephalinase inhibitor useful in the treatment of diarrhea. Vixotrigine Vixotrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. Danoprevir Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic. Tilarginine Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. Danegaptide Danegaptide has been investigated for the treatment of Focus of Study is STEMI. Astodrimer Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups. Valbenazine A vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia and chorea associated with Huntington's disease. Vaniprevir Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C... Delanzomib Delanzomib has been used in trials studying the treatment of Solid Tumors, Multiple Myeloma, and Lymphoma, Non-Hodgkin. Nirogacestat Nirogacestat has been used in trials studying the treatment of Breast Cancer, HIV Infection, Desmoid Tumors, Advanced Solid Tumors, and Aggressive Fibromatosis, among others. MK-0893 MK0893 has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2. Bucillamine Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis. ORE-1001 ORE1001 has been used in trials studying the treatment of Mild to Moderate Ulcerative Colitis. It is an ACE2 inhibitor. PD-217014 PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome. Iofolastat I-123 Iofolastat I-123 is under investigation in clinical trial NCT00992745 (A Phase I Pilot Study Comparing 123I MIP 1072 Versus 111In Capromab Pendetide in Subjects With Metastatic Prostate Cancer). Decernotinib Decernotinib has been used in trials studying the treatment of Drug Interactions and Rheumatoid Arthritis. 3,5-diiodothyropropionic acid DITPA has been investigated in Congestive Heart Failure. N-omega-nitro-L-arginine methyl ester L-NAME has been investigated for the treatment of Hypotension and Spinal Cord Injury. Ombrabulin Ombrabulin has been used in trials studying the treatment of Sarcoma, Neoplasms, Solid Tumor, Neoplasms, Malignant, and Advanced Solid Tumors, among others. Pivagabine Pivagabine has been used in trials studying the treatment of Stress and Anxiety. PCI-27483 PCI-27483 has been used in trials studying the treatment of Pancreatic Cancer, Ductal Adrenocarcinoma, and Exocrine Pancreatic Cancer. Macimorelin A medication used to treat adult growth hormone deficiency. Tiropramide A medication indicated in the treatment of spastic pain of the gastrointestinal system. Zofenopril An ACE inhibitor indicated in the treatment of hypertension. Phosphocreatine A cardioprotective agent indicated for use in cardiac surgery. Acetylleucine Used for treating vestibular-related imbalance and vertigo. Melevodopa A methyl ester of levodopa indicated in combination with carbidopa for the treatment of Parkinson's disease. Magnesium aspartate Magnesium aspartate is a magnesium salt of aspartic acid that is commonly used as a mineral supplement. It displays high oral bioavailability and water solubiltiy compared to other magnesium salts... Oxaceprol Not Annotated Proglumide Not Annotated Phenibut Not Annotated Calcium pangamate Not Annotated Paclitaxel poliglumex Not Annotated Netarsudil A rho kinase inhibitor used to reduce intraocular pressure in patients with open angle glaucoma or ocular hypertension. Nordazepam A benzodiazepine indicated in the treatment of insomnia. Hopantenic acid Hopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal... Methionine sulfoximine Not Annotated Fosinoprilat Fosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group. Telotristat A tryptophan hydroxylase inhibitor. Telotristat ethyl (brand name Xermelo) is a prodrug of telotristat. Acetylcysteine zinc Not Available Acetylcysteine amide Not Available Narlaprevir Not Annotated Piflufolastat F 18 A radiopharmaceutical diagnostic agent used with PET to image PSMA-positive lesions for the diagnosis of metastatic or recurrent prostate cancer. Demplatin pegraglumer Demplatin pegraglumer is under investigation in clinical trial NCT02043288 (Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer). BMS-817399 BMS-817399 is under investigation in clinical trial NCT01404585 (Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis). Enarodustat Enarodustat is under investigation in clinical trial NCT02581124 (Study to Evaluate Effect of Lapatinib on Pharmacokinetics of JTZ-951 in Subjects With End-stage Renal Disease). PF-06291874 PF-06291874 is under investigation in clinical trial NCT02175121 (Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study of PF-06291874 as Oral Monotherapy To Treat Adults With Type 2 Diabetes Mellitus). GS-9191 GS-9191 is under investigation in clinical trial NCT00499967 (Safety and Effectiveness Study of an Experimental Topical Ointment (GS-9191) for the Treatment of Genital Warts). Somapacitan A human growth hormone analog subcutaneous injection indicated for adults with growth hormone deficiency. Ciraparantag Ciraparantag is under investigation in clinical trial NCT01826266 (Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban). Danicopan Danicopan is under investigation in clinical trial NCT03459443 (A Proof of Concept Study for a 12 Month Treatment in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN)). Norleucine Norleucine is under investigation in clinical trial NCT00081952 (Amino Acid Therapy for Hot Flashes in Postmenopausal Women). Efpeglenatide Efpeglenatide is under investigation in clinical trial NCT03713684 (Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Alone or in... Ravidasvir Ravidasvir is under investigation in clinical trial NCT02961426 (Sofosbuvir Plus Ravidasvir for the Treatment of HCV Chronic Infection). MK-0668 Not Annotated GC-376 free acid GC-376 is a 3C-like protease (3CLpro or Mpro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells . The compound... Potassium aspartate A potassium supplement used to treat hypokalemia or hyperammonemia. Desmeninol An amino acid derivative indicated in the management of balanced protein metabolism in patients with renal dysfunction. Gamma-amino-beta-hydroxybutyric acid An anticonvulsant indicated to treat convulsions in children and epilepsy. Arginine aspartate An ingredient in products indicated to treat exhaustion during stress, endurance sports, or in the elderly. TRC150094 TRC150094 is under investigation in clinical trial NCT03254446 (Safety and Efficacy Study of TRC150094 to Improve the CV Risk in Subjects With Diabetes, Dyslipidemia and Hypertension). Carotegrast methyl Carotegrast methyl is under investigation in clinical trial NCT03531892 (A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis). Denagliptin Denagliptin is under investigation in clinical trial NCT00387972 (Study of Denagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM)). Fasoracetam Fasoracetam is under investigation in clinical trial NCT03609619 (PART B: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and Without Mglur Mutations). PF-07304814 PF-07304814 is a small molecule prodrug that targets the 3CLpro protease (Mpro), which is used by viruses like SARS-CoV-2 to assemble and multiply . Once administered through intravenous infusion, the... Metadoxine A medication used to increase the clearance of alcohol in patients with chronic alcohol dependancy. Nirmatrelvir An oral protease inhibitor with emergency use authorization for the treatment of mild-to-moderate COVID-19. RG-2833 Not Annotated L-Acetylleucine Not Annotated Phosphopantothenic acid Not Annotated Phenylacetylglutamine Not Annotated L-arginine Not Annotated Hiltonol Not Available Heme arginate Not Available 6-diazo-5-oxo-L-norleucine 6-diazo-5-oxo-L-norleucine is a broad-acting glutamine antagonist. GC-373 GC-373 is a peptide aldehyde which is metabolized from the bisulfide adduct, GC-376 free acid[A219031,A219036]. It is an inhibitor of Mpro (otherwise known as 3CLpro), a viral encoded protease that... Ergothioneine Not Annotated K-777 Not Annotated Nacystelyn Not Annotated CPP-115 free base Not Annotated Nano-diamino-tetrac Not Annotated Aloxistatin Not Annotated Nanvuranlat Not Annotated Cyclocreatine Not Annotated Chromium histidinate Not Annotated
- Drugs & Drug Targets