Adafosbuvir

DB14906InvestigationalSmall molecule

Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335).

Mechanism: Pharmacologically active on RNA-directed RNA polymerase
Curator reviewed
Formula / weight: C₂₂H₂₉FN₃O₁₀P · 545.457 g/mol (avg)
Code names: AL-335

Resolves to

Compound

UNIIS83770Y75RCAS1613589-09-5

Structure

InChIKeyNIJYGVDQZBBONK-SEUXLIJBSA-NSMILESCC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@@]1(F)O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(O)[C@@H]1O)OC1=CC=CC=C1

Targets

O39930NS5b

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

14Drug interactionsStructured to mechanism, not free text

7Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Adafosbuvir, and which of those have an active Phase 3 trial?

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