Purines
- Name
- Purines
- Accession Number
- DBCAT000253
- Description
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
- Drugs
Drug Drug Description Adenine A purine base which forms a component of DNA among other functions and is present in many multivitamins. Vidarabine An antiviral agent used to treat various viral infections. Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Cladribine A purine antimetabolite used to treat Multiple Sclerosis (MS) and hairy cell leukemia. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Penciclovir A topical nucleoside polymerase inhibitor used in the treatment of recurrent herpes labialis. Tenofovir disoproxil A nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection. Tioguanine A purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias. Famciclovir A nucleoside analog DNA polymerase inhibitor used for the treatment of recurrent cold sores and genital herpes in healthy patients and patients with HIV, and to manage herpes zoster. Allopurinol A xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies. Valaciclovir An guanine nucleoside antiviral used to treat herpes exacerbations. Clofarabine A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Acyclovir A guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Didanosine A reverse transcriptase inhibitor used to treat HIV. Dimenhydrinate A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness. Ganciclovir A DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. Mercaptopurine An antineoplastic agent used to treat acute lymphocytic leukemia. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Oxtriphylline A bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema. Flavin adenine dinucleotide A coenzyme form of vitamin B2 used in clinical conditions associated with vitamin B2 deficiency. Cangrelor A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Linagliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Tenofovir alafenamide A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease. Kinetin Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. It was shown to naturally exist in DNA of organisms including humans and various plants. While... Galidesivir Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various... Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Bromotheophylline Bromotheophylline is used as a diuretic and also, in combination with DB00316, it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with... Tenofovir A nucleotide analog indicated in the treatment of HIV infections. Azathioprine An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Seliciclib Investigated for use/treatment in breast cancer, lung cancer, lymphoma (unspecified), multiple myeloma, leukemia (lymphoid), and cancer/tumors (unspecified). Adenosine phosphate For nutritional supplementation, also for treating dietary shortage or imbalance Entecavir A nucleoside analogue used in the treatment of chronic hepatitis B for patients with active viral replication, histological evidence of active disease, or persistent elevations in liver transaminases. Adefovir dipivoxil A nucleotide analog used to treat chronic hepatitis B. 8-azaguanine 8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. 7,9-Dimethylguanine Not Available 7-Deazaguanine Not Available 5'-S-methyl-5'-thioadenosine Not Available Guanine Not Available 9-Methylguanine Not Available Peldesine Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections. 7-cyano-7-deazaguanine Not Available D-Eritadenine Not Available 9-Deazahypoxanthine Not Available 3-Methyladenine Not Available 9-Deazaguanine Not Available Nebularine Not Available (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol Not Available Besifovir dipivoxil Investigated for use/treatment in hepatitis (viral, B). Amonafide Investigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer. Pradefovir mesylate Investigated for use as a prodrug for Hepsera in treating hepatitis (viral, B). Valomaciclovir Investigated for use/treatment in herpes zoster infections and viral infection. GS 0573 Not Annotated Ibrutinib An antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. 6-O-benzylguanine 6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others. BIIB021 BIIB021 has been investigated for the treatment of Tumors and Lymphoma. Lobucavir Lobucavir has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. Adefovir Not Annotated Queuine Current and on-going research suggests queuine is a natural biochemical compound that can be found endogenously in the human body and plays an essential role in the generation of other... Rovafovir etalafenamide Rovafovir etalafenamide is under investigation in clinical trial NCT03472326 (Efficacy of GS-9131 Functional Monotherapy in HIV-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen). Tenofovir exalidex Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers). Pradefovir Pradefovir is a prodrug of adefovir. Valomaciclovir stearate Valomaciclovir stearate is under investigation in clinical trial NCT00831103 (A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster). Besifovir Not Annotated GSK2245035 GSK2245035 is under investigation in clinical trial NCT02833974 (Effect of the GSK2245035 on the Allergen-induced Asthmatic Response). Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... NADH A nutrient used in some supplement products. ATP For nutritional supplementation, also for treating dietary shortage or imbalance Enprofylline Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Theobromine theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. Fenethylline Not Available Valganciclovir An antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS). 4-hydroxybenzoyl-CoA Not Available 1-(5-phospho-D-ribosyl)-ATP Not Available Methacrylyl-Coenzyme A Not Available S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. (Rp)-cAMPS Not Available Adenosine 3',5'-diphosphate Not Available Desulfo-coenzyme A Not Available Cordycepin Triphosphate Not Available 8-azaxanthine Not Available Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... Guanosine-2'-monophosphate Not Available Coenzyme A Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric... 8-oxo-dGMP Not Available Phosphoaminophosphonic acid guanylate ester A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the... Olomoucine Not Available Xanthine A drug used to manage uncomplicated liver dysfunction in combination with orotic acid. Myristoyl-Coa Not Available 2',3'-Dideoxyadenosine triphosphate Not Available Cyclic GMP Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular... NADPH Not Available Deoxyinosine Not Available 8-hydroxy-2'-deoxyguanosine Not Available Cyclic adenosine monophosphate Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP). Hexanoyl-CoA Not Available alpha,beta-Methyleneadenosine 5'-triphosphate Not Available Adenosine Phosphonoacetic Acid Not Available 6-hydroxy-FAD Not Available 9-deazainosine Not Available S-Adenosyl-1,8-Diamino-3-Thiooctane Not Available Guanosine Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP... Methylthioinosine An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. Octanoyl-Coenzyme A Not Available Propanoyl-CoA Not Available Adenosine 5'-[gamma-thio]triphosphate A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur. Acetoacetyl-CoA Not Available Mant-Adp Not Available Adenosine 5'-methylenediphosphate Not Available Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... dATP Not Available Guanosine 3'-monophosphate Not Available Deoxycytidylyl-3',5'-guanosine Not Available 3-Acetylpyridine Adenine Dinucleotide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available Nicotinamide adenine dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of... 7-Methylguanosine Not Available 7-methyl-5'-guanylic acid Not Available 3-Hydroxybutyryl-Coenzyme A Not Available Succinyl-Coenzyme A Not Available Adenosine 5'-phosphosulfate 5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS. 5'-Fluoro-5'-Deoxyadenosine Not Available 5'-Guanylylmethylenebisphosphonate Not Available Guanosine tetraphosphate Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2'... Coenzyme A persulfide Coenzyme A persulfide is a possible in vivo inhibitor of mammalian short chain acyl-CoA dehydrogenase. (R)-methylmalonyl-CoA Not Available Hypoxanthine Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. Inosine A nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. Adenylosuccinic acid Not Available 2-Fluoroadenosine Not Available Malonyl-CoA A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. 3-Deazaadenosine Not Available Inosinic Acid Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. 5-iodotubercidin Not Available Binodenoson For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease. Isatoribine For the treatment of Hepatitis C. Tecadenoson Investigated for use/treatment in arrhythmia and atrial fibrillation. Apadenoson Investigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified). Piclidenoson Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used... Regrelor Investigated for use/treatment in cardiac surgery, coronary artery disease, thrombosis, and transfusion. Forodesine Investigated for use/treatment in lymphoma (non-hodgkin's) and leukemia (lymphoid). Naxifylline Investigated for use/treatment in congestive heart failure. Propentofylline Investigated for use/treatment in alzheimer's disease. Amdoxovir Investigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections. 3-isobutyl-1-methyl-7H-xanthine Not Available Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... N(6)-dimethylallyladenine Not Available Uric acid At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke. Xanthinol A vasodilatory niacin found in diet supplements. Doxofylline A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Zeatin An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed) BMS-986094 INX-08189 has been used in trials studying the treatment of Hepatitis C, HCV (Genotype 1), and Hepatitis C Virus. Cordycepin Cordycepin has been used in trials studying the treatment of Leukemia. Lisofylline Lisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus. Sonedenoson Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications. Tonapofylline Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure. Rolofylline Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure. UK-432097 UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. NB-001 NB-001 has been investigated for the treatment of Recurrent Herpes Labialis. Reproterol A short-acting β2 adrenoreceptor agonist used to treat various types of asthma including allergic asthma, non-allergic asthma, and exercise-induced asthma. Cafedrine Cafedrine is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Theodrenaline Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). DPCPX CPX has been used in trials studying the treatment of Cystic Fibrosis. Neosaxitoxin Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic). Tocladesine Tocladesine has been used in trials studying the treatment of Colorectal Cancer and Multiple Myeloma and Plasma Cell Neoplasm. CT-2584 CT-2584 has been used in trials studying the treatment of Prostate Cancer. Trabodenoson Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG). Ambroxol acefyllinate A bronchodilator indicated in the symptomatic treatment of bronchopulmonary disorders associated with bronchospasm. Bamifylline A methylxanthine derivative indicated in the treatment of bronchial asthma and other conditions with bronchospasm. Bucladesine Not Annotated Proxyphylline Not Annotated Acefylline Not Annotated Etamiphylline Not Annotated Pentifylline Not Annotated Tisopurine Not Annotated Bufylline Not Annotated Furafylline Furafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for theophylline. Nadide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... 8-chlorotheophylline When used in combination with DB01075 as the antiemetic DB00985, 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness. Remdesivir A nucleoside analog used to treat RNA virus infections including COVID-19. AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). PCS-499 PCS-499 is under investigation in clinical trial NCT01487109 (A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients). KRN-5500 KRN-5500 is under investigation in clinical trial NCT00002923 (KRN5500 in Treating Patients With Metastatic Solid Tumors). GS-6620 GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection). CYC-065 CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL). Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). GS-441524 An experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections. 8-Chloroadenosine 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia). Selodenoson Selodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation). AT-527 Not Available Bentracimab Bentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure). Adenosine disphosphate Not Annotated AMG-319 Not Annotated NS13001 Not Annotated Namodenoson Namodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma. Loxoribine Not Available Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Sapanisertib Sapanisertib has been used in trials studying the treatment of HCC, Solid Tumor, Gliosarcoma, Liver Cancer, and Glioblastoma, among others. Abacavir hydroxyacetate Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis. Ibezapolstat Ibezapolstat is under investigation in clinical trial NCT04247542 (ACX-362E Ibezapolstat for Oral Treatment of Clostridioides Difficile Infection). Allopurinol riboside Allopurinol riboside is a nucleoside analogue of allopurinol with a beta-D-ribofuranosyl moiety at the 1-position. Dideoxyadenosine Not Annotated Lomifylline Not Annotated 2'-deoxythioguanosine Not Annotated Obeldesivir Not Available Metacavir Metacavir is under investigation in clinical trial NCT02965859 (The Safety and Dose-range Study of Metacavir Enteric-coated Capsules in Patients With Chronic Hepatitis B). Gonyautoxin II Gonyautoxin II is under investigation in clinical trial NCT04799041 (Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study). Gonyautoxin III Gonyautoxin III is currently under investigation in clinical trial (Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study) for the treatment of Acute Back Pain. Honokiol Honokiol is under investigation in clinical trial NCT00966953 (Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.). - Drugs & Drug Targets