6-O-benzylguanine

DB11919InvestigationalSmall molecule

6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others.

Chemical structure of 6-O-benzylguanine
Formula / weight
C12H11N5O · 241.2486 g/mol (avg)
Also known as
O(6)-Benzylguanine · O6-benzylguanine
Code names
NSC-637037

Resolves to

Compound
UNII01KC87F8FECAS19916-73-5ChEMBLCHEMBL407874PubChem4578
Structure
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-NSMILESNC1=NC(OCC2=CC=CC=C2)=C2N=CNC2=N1
Targets
P16455MGMT

What you can answer from here — as of January 29, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
714Drug interactionsStructured to mechanism, not free text
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27Clinical trialsPhase, status and sponsor resolved per trial
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4+ReferencesStructured and connected to the statements they support
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Which drugs share a target with 6-O-benzylguanine, and which of those have an active Phase 3 trial?

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