Nucleic Acids, Nucleotides, and Nucleosides
- Nucleic Acids, Nucleotides, and Nucleosides
- Accession Number
Complex compounds of high molecular weight occurring in living cells. These are basically of two types, ribonucleic (RNA) and deoxyribonucleic (DNA) acids, both of which consist of nucleotides (nucleoside phosphates linked together by phosphate bridges).
Drug Drug Description Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Adenosine phosphate For nutritional supplementation, also for treating dietary shortage or imbalance NADH A nutrient used in some supplement products. ATP For nutritional supplementation, also for treating dietary shortage or imbalance Vidarabine An antiviral agent used to treat various viral infections. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Idoxuridine A pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. Floxuridine An antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy. Trifluridine A nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers. Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Pentostatin An adenosine deaminase inhibitor used to treat hairy cell leukemia. Clofarabine A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Stavudine A dideoxynucleoside used in the treatment of HIV infection. Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Ribavirin A guanosine nucleoside used to treat some forms of Hepatitis C. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Didanosine A reverse transcriptase inhibitor used to treat HIV. Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. Zalcitabine A dideoxynucleoside used to treat HIV. Cytarabine A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. Azathioprine An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Capecitabine A nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer. Decitabine A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression. Telbivudine A thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST). Nelarabine A purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments. 5-fluorouridine 5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine... Thymidine monophosphate 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety. 4-hydroxybenzoyl-CoA Not Available 1-(5-phospho-D-ribosyl)-ATP Not Available Methacrylyl-Coenzyme A Not Available AICA ribonucleotide 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has... Desulfo-coenzyme A Not Available Cordycepin Triphosphate Not Available Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... Coenzyme A Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric... Cytidine Not Available Myristoyl-Coa Not Available Glycinamide Ribonucleotide Not Available Formycin Not Available 5'-S-methyl-5'-thioadenosine Not Available Deoxyinosine Not Available 8-hydroxy-2'-deoxyguanosine Not Available Cyclic adenosine monophosphate Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP). Hexanoyl-CoA Not Available Adenosine Phosphonoacetic Acid Not Available Uridine Not Available 9-deazainosine Not Available S-Adenosyl-1,8-Diamino-3-Thiooctane Not Available Guanosine Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP... Methylthioinosine An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. Octanoyl-Coenzyme A Not Available UDP-alpha-D-glucuronic acid A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides.... Zebularine A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also... Mant-Adp Not Available Flavin adenine dinucleotide A coenzyme form of vitamin B2 used in clinical conditions associated with vitamin B2 deficiency. Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... dATP Not Available Nicotinamide Mononucleotide 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN. [PubChem] Deoxycytidylyl-3',5'-guanosine Not Available 3-Acetylpyridine Adenine Dinucleotide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... 7-Methylguanosine Not Available Galactose-uridine-5'-diphosphate A nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides,... 3-Hydroxybutyryl-Coenzyme A Not Available Succinyl-Coenzyme A Not Available 5'-Fluoro-5'-Deoxyadenosine Not Available 6-aza uridine 5'-monophosphate Not Available Deoxyuridine monophosphate Not Available Coenzyme A persulfide Coenzyme A persulfide is a possible in vivo inhibitor of mammalian short chain acyl-CoA dehydrogenase. (R)-methylmalonyl-CoA Not Available Formycin B Not Available Inosine A nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. 3-Deazacytidine Not Available Adenylosuccinic acid Not Available Nebularine Not Available 2-Fluoroadenosine Not Available Thymidine Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in... 5-iodotubercidin Not Available Cyclouridine Not Available Cyclic 3',5'-thymidine monophosphate Not Available Binodenoson For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease. Isatoribine For the treatment of Hepatitis C. Pegaptanib A selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration. Amolimogene Intended for the treatment of cervical dysplasia associated with the human papillomavirus (HPV). Defibrotide A mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation. Acadesine Investigated for use/treatment in cardiac reperfusion injury, cardiovascular disorders, and coronary artery disease. Tecadenoson Investigated for use/treatment in arrhythmia and atrial fibrillation. LErafAON Intended for the treatment of various forms of cancer. Denufosol For use as an inhaled treatment for cystic fibrosis. AGRO100 Investigated for use/treatment in cancer/tumors (unspecified), kidney cancer, leukemia (myeloid), and pancreatic cancer. Apadenoson Investigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified). R1626 Investigated for use/treatment in hepatitis (viral, C). Thymectacin Investigated for use/treatment in colorectal cancer. LY2181308 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. LY2275796 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. Egaptivon pegol Platelet aggregation, thrombosis and acute coronary syndromes GTI-2501 Investigated for use/treatment in prostate cancer and solid tumors. Custirsen Investigated for use/treatment in brain cancer and breast cancer. Elacytarabine Investigated for use/treatment in leukemia (unspecified) and melanoma. Piclidenoson Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used... Mipomersen An oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia. CPG 10101 Investigated for use/treatment in hepatitis (viral, C) and viral infection. Regrelor Investigated for use/treatment in cardiac surgery, coronary artery disease, thrombosis, and transfusion. KP-1461 Investigated for use/treatment in HIV infection. GEM-231 Investigated for use/treatment in solid tumors. OSI-7836 Investigated for use/treatment in solid tumors. Eteplirsen An antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation. Apatorsen Investigated for use/treatment in cancer/tumors (unspecified). AEG35156 Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid). Forodesine Investigated for use/treatment in lymphoma (non-hodgkin's) and leukemia (lymphoid). Alovudine Investigated for use/treatment in HIV infection. Alicaforsen Investigated for use/treatment in crohn's disease and ulcerative colitis. Maribavir Investigated for use/treatment in viral infection, transplantation (organ or tissue), cytomegalovirus (CMV) retinitis, and retinal disorders (unspecified). Elvucitabine Investigated for use/treatment in hepatitis (viral, B) and HIV infection. Pegnivacogin Investigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases. Sapacitabine Investigated for use/treatment in solid tumors, cutaneous t-cell lymphoma, myelodysplastic syndrome, and leukemia (lymphoid). Taribavirin Investigated for use/treatment in hepatitis (viral, C). Tezacitabine Investigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer. Cangrelor A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Aprinocarsen Investigated for use/treatment in lung cancer. Edifoligide Investigated for use/treatment in cardiac surgery, peripheral vascular disease, and kidney disease. Amdoxovir Investigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections. Bevasiranib Investigated for use/treatment in macular degeneration and diabetic retinopathy. TAS-106 Investigated for use/treatment in solid tumors and cancer/tumors (unspecified). Abetimus Investigated for use/treatment in kidney disease and systemic lupus erythematosus. Clevudine Investigated for use/treatment in hepatitis (viral, B). Fomivirsen Indicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428]. Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Sofosbuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. TAS-102 TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. It is composed of the thymidine phosphorylase... Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer. Galidesivir Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various... Guadecitabine Guadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer. BMS-986094 INX-08189 has been used in trials studying the treatment of Hepatitis C, HCV (Genotype 1), and Hepatitis C Virus. Sorivudine Sorivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. Broxuridine Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer. Mericitabine Mericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of... Censavudine Censavudine has been used in trials studying the treatment of HIV-1 Infection. Cordycepin Cordycepin has been used in trials studying the treatment of Leukemia. Balapiravir Balapiravir has been used in trials studying the treatment of Dengue and Hepatitis C, Chronic. Triciribine Triciribine has been used in trials studying the treatment of Leukemia, Ovarian Cancer, HER2/Neu Negative, Breast Adenocarcinoma, and Stage IV Breast Cancer, among others. Fozivudine Tidoxil Fozivudine Tidoxil has been used in trials studying the treatment of HIV Infections. Sonedenoson Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications. Dexelvucitabine Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. Tetrahydrouridine Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others. Gemcitabine elaidate Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma. Netivudine Netivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. UK-432097 UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. NB-001 NB-001 has been investigated for the treatment of Recurrent Herpes Labialis. Racivir Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of emtricitabine DB00879 and its positive enantiomer. Racivir... Miravirsen Miravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic. Apricitabine Apricitabine has been used in trials studying the treatment of HIV Infections. Raluridine Raluridine has been used in trials studying the treatment of HIV Infections. PSI-352938 PSI-352938 has been used in trials studying the treatment of Hepatitis C and Hepatitis C, Chronic. Fiacitabine Fiacitabine has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. LY-2334737 LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor. Doxifluridine Doxifluridine has been investigated for the treatment of Stomach Cancer. 5-fluoro-2'-deoxycytidine 5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others. 2'-fluoro-5-ethylarabinosyluracil 2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma,... Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Nusinersen A medication used to treat spinal muscular atrophy. Tunicamycin Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes... Bucladesine Not Annotated Tiazofurine Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase . Edoxudine A deoxythymidine analog used to treat herpetic keratitis. Drisapersen Not Annotated Oblimersen Not Annotated Toyocamycin 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. Valopicitabine The 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite... 2'-C-methylcytidine A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks... Trabodenoson Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG). Nadide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... Patisiran A transthyretin-directed small interfering RNA used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. Triciribine phosphate Not Annotated Ribavirin monophosphate Not Annotated S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. Uridine diphosphate glucose A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and... 3'-Uridinemonophosphate Not Available Propanoyl-CoA Not Available Adenosine 5'-[gamma-thio]triphosphate A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur. Acetoacetyl-CoA Not Available Flavin mononucleotide A form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia. 2'-Deoxycytidine 5'-triphosphate Not Available Brivudine Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries. Guanosine 3'-monophosphate Not Available Cytidine-5'-Monophosphate A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase. Uridine monophosphate 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position. Adenosine 5'-phosphosulfate 5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS. Uridine 5'-triphosphate Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. Malonyl-CoA A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. Citicoline Citicoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. It has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar... IMO-2055 Investigated for use/treatment in renal cell carcinoma, solid tumors, and lung cancer. ISS-1018 Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent... Cyclic GMP Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular... Remdesivir A nucleoside analog used to treat RNA virus infections including COVID-19. NF-kappaB Decoy Investigated for use/treatment in atopic dermatitis, inflammatory disorders (unspecified), and skin infections/disorders. Lumicitabine Lumicitabine is under investigation in clinical trial NCT03010059 (A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to... AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). Alovudine F-18 Alovudine F-18 is under investigation in clinical trial NCT02819024 (Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography). Mongersen Mongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult... GTI-2040 GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors). NUC-1031 NUC-1031 is under investigation in clinical trial NCT03610100 (Acelarin First Line Randomised Pancreatic Study). Volanesorsen An antisense oligonucleotide indicated to treat familial chylomicronemia. KRN-5500 KRN-5500 is under investigation in clinical trial NCT00002923 (KRN5500 in Treating Patients With Metastatic Solid Tumors). ARC-19499 ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients). Aganirsen Aganirsen is under investigation in clinical trial NCT02947867 (Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG). Fialuridine Fialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU). Cenersen Cenersen is under investigation in clinical trial NCT02243124 (A Study of Aezea® (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome (MDS)). Lexaptepid pegol Lexaptepid pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease. Tocladesine Tocladesine has been used in trials studying the treatment of Colorectal Cancer and Multiple Myeloma and Plasma Cell Neoplasm. Inotersen An antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. Danvatirsen Danvatirsen is under investigation in clinical trial NCT03334617 (Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy.). Inclisiran A PCSK9-targeted short interfering RNA that lowers plasma LDL-cholesterol levels. Adafosbuvir Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335). Imetelstat Imetelstat is under investigation in clinical trial NCT01916187 (Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma). TAK-243 TAK-243 is under investigation in clinical trial NCT03816319 (TAK-243 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Refractory Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia). Uprifosbuvir Uprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and... GS-6620 GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection). Radavirsen Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza). CYC-065 CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL). Adenylyl-(3'-5')-uridine 3'-monophosphate Not Available 5'-Guanosine-Diphosphate-Monothiophosphate Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation,... 8-oxo-dGMP Not Available 7-methyl-5'-guanylic acid Not Available Guanosine-2'-monophosphate Not Available 5-methylcytidine 5'-monophosphate Not Available Phosphoaminophosphonic acid guanylate ester A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the... 6-hydroxy-FAD Not Available Nicotinamide adenine dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of... Zidovudine monophosphate Not Available 5'-Guanylylmethylenebisphosphonate Not Available 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available Guanosine tetraphosphate Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2'... Zidovudine diphosphate Not Available 3-Deazaadenosine Not Available TMP Not Available N(6)-dimethylallyladenine Not Available Dichlororibofuranosylbenzimidazole Not Available NADPH Not Available Stavudine triphosphate Not Available Adenosine 3',5'-diphosphate Not Available 2',3'-Dideoxyadenosine triphosphate Not Available Thymidine 5'-triphosphate Not Available alpha,beta-Methyleneadenosine 5'-triphosphate Not Available Orotidylic acid Not Available Adenosine 5'-methylenediphosphate Not Available Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). N4-Hydroxycytidine A cytidine analog being investigated to treat COVID-19. (Rp)-cAMPS Not Available Viltolarsen An antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations. Diquafosol Not Annotated Lumasiran Lumasiran is an interfering RNA that silences hydroxyacid oxidase 1 for the treatment of primary hypoxaluria type 1. 8-Chloroadenosine 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia). Anivamersen Anivamersen is under investigation in clinical trial NCT01848106 (A Study to Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI). Fluorocyclopentenylcytosine Fluorocyclopentenylcytosine is under investigation in clinical trial NCT03189914 (RX-3117 in Combination With Abraxane® in Subjects With Metastatic Pancreatic Cancer). ISIS 2503 ISIS 2503 is under investigation in clinical trial NCT00004193 (ISIS 2503 in Treating Patients With Metastatic And/or Locally Recurrent Colorectal Cancer). ISIS 104838 ISIS 104838 is under investigation in clinical trial NCT00048321 (ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid Arthritis). Revusiran Revusiran is under investigation in clinical trial NCT02319005 (ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)). Selodenoson Selodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation). Azvudine Azvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)). Rintatolimod Not Annotated Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping. Bentracimab Bentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure).
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