Nucleotides
- Name
- Nucleotides
- Accession Number
- DBCAT000292
- Description
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
- Drugs
Drug Drug Description Pegaptanib A selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration. Thymectacin Investigated for use/treatment in colorectal cancer. Fomivirsen Indicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428]. Remdesivir A nucleoside analog used to treat RNA virus infections including COVID-19. Volanesorsen An antisense oligonucleotide indicated to treat familial chylomicronemia. Viltolarsen An antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations. Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping. Adenosine phosphate For nutritional supplementation, also for treating dietary shortage or imbalance NADH A nutrient used in some supplement products. ATP For nutritional supplementation, also for treating dietary shortage or imbalance Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Clofarabine A purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Thymidine monophosphate 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety. 4-hydroxybenzoyl-CoA Not Available 1-(5-phospho-D-ribosyl)-ATP Not Available Methacrylyl-Coenzyme A Not Available AICA ribonucleotide 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has... (Rp)-cAMPS Not Available Adenylyl-(3'-5')-uridine 3'-monophosphate Not Available Adenosine 3',5'-diphosphate Not Available Desulfo-coenzyme A Not Available Cordycepin Triphosphate Not Available Uridine diphosphate glucose A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and... 5'-Guanosine-Diphosphate-Monothiophosphate Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation,... Guanosine-2'-monophosphate Not Available Cytidine 3'-monophosphate Not Available Coenzyme A Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric... 5-methylcytidine 5'-monophosphate Not Available 8-oxo-dGMP Not Available Phosphoaminophosphonic acid guanylate ester A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the... Myristoyl-Coa Not Available 2',3'-Dideoxyadenosine triphosphate Not Available Glycinamide Ribonucleotide Not Available Cyclic GMP Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular... NADPH Not Available Thymidine 5'-triphosphate Not Available Cyclic adenosine monophosphate Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP). Hexanoyl-CoA Not Available alpha,beta-Methyleneadenosine 5'-triphosphate Not Available Adenosine Phosphonoacetic Acid Not Available 6-hydroxy-FAD Not Available 3'-Uridinemonophosphate Not Available Stavudine triphosphate Not Available Octanoyl-Coenzyme A Not Available Propanoyl-CoA Not Available Adenosine 5'-[gamma-thio]triphosphate A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur. Orotidylic acid Not Available UDP-alpha-D-glucuronic acid A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides.... Acetoacetyl-CoA Not Available Mant-Adp Not Available Flavin adenine dinucleotide A coenzyme form of vitamin B2 used in clinical conditions associated with vitamin B2 deficiency. Adenosine 5'-methylenediphosphate Not Available dATP Not Available Nicotinamide Mononucleotide 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN. [PubChem] Flavin mononucleotide A form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia. 2'-Deoxycytidine 5'-triphosphate Not Available Guanosine 3'-monophosphate Not Available Deoxycytidylyl-3',5'-guanosine Not Available 3-Acetylpyridine Adenine Dinucleotide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... Cytidine-5'-Monophosphate A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase. Nicotinamide adenine dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of... Galactose-uridine-5'-diphosphate A nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides,... 7-methyl-5'-guanylic acid Not Available 3-Hydroxybutyryl-Coenzyme A Not Available Zidovudine monophosphate Not Available Uridine monophosphate 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position. Succinyl-Coenzyme A Not Available Adenosine 5'-phosphosulfate 5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS. 6-aza uridine 5'-monophosphate Not Available 2'-Deoxy-thymidine-beta-L-rhamnose Not Available 5'-Guanylylmethylenebisphosphonate Not Available 5-fluoro-2'-deoxyuridine-5'-monophosphate Not Available 2'-cytidylic acid Not Available Deoxyuridine monophosphate Not Available Uridine 5'-triphosphate Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. Guanosine tetraphosphate Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2'... Coenzyme A persulfide Coenzyme A persulfide is a possible in vivo inhibitor of mammalian short chain acyl-CoA dehydrogenase. (R)-methylmalonyl-CoA Not Available TMP Not Available Adenylosuccinic acid Not Available Malonyl-CoA A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. Zidovudine diphosphate Not Available Inosinic Acid Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. Cyclic 3',5'-thymidine monophosphate Not Available Defibrotide A mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation. LErafAON Intended for the treatment of various forms of cancer. Denufosol For use as an inhaled treatment for cystic fibrosis. AGRO100 Investigated for use/treatment in cancer/tumors (unspecified), kidney cancer, leukemia (myeloid), and pancreatic cancer. LY2181308 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. LY2275796 Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors. Egaptivon pegol Platelet aggregation, thrombosis and acute coronary syndromes GTI-2501 Investigated for use/treatment in prostate cancer and solid tumors. ISS-1018 Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent... Custirsen Investigated for use/treatment in brain cancer and breast cancer. Mipomersen An oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia. CPG 10101 Investigated for use/treatment in hepatitis (viral, C) and viral infection. Regrelor Investigated for use/treatment in cardiac surgery, coronary artery disease, thrombosis, and transfusion. NF-kappaB Decoy Investigated for use/treatment in atopic dermatitis, inflammatory disorders (unspecified), and skin infections/disorders. Trabedersen Investigated for use/treatment in brain cancer, colorectal cancer, melanoma, and pancreatic cancer. GEM-231 Investigated for use/treatment in solid tumors. Archexin Investigated for use/treatment in solid tumors. Eteplirsen An antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene that is amenable to exon 51 skipping. Apatorsen Investigated for use/treatment in cancer/tumors (unspecified). IMO-2055 Investigated for use/treatment in renal cell carcinoma, solid tumors, and lung cancer. AEG35156 Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid). Alicaforsen Investigated for use/treatment in crohn's disease and ulcerative colitis. Pegnivacogin Investigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases. Cangrelor A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST). Aprinocarsen Investigated for use/treatment in lung cancer. Edifoligide Investigated for use/treatment in cardiac surgery, peripheral vascular disease, and kidney disease. Abetimus Investigated for use/treatment in kidney disease and systemic lupus erythematosus. Sofosbuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. BMS-986094 INX-08189 has been used in trials studying the treatment of Hepatitis C, HCV (Genotype 1), and Hepatitis C Virus. Citicoline An endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. Lexaptepid pegol Lexaptepid pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease. NB-001 NB-001 has been investigated for the treatment of Recurrent Herpes Labialis. Miravirsen Miravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic. Tocladesine Tocladesine has been used in trials studying the treatment of Colorectal Cancer and Multiple Myeloma and Plasma Cell Neoplasm. Nusinersen A medication used to treat spinal muscular atrophy. Bucladesine Not Annotated Drisapersen Not Annotated Oblimersen Not Annotated Nadide A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves... Triciribine phosphate Not Annotated Inotersen An antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. Tofersen Tofersen is under investigation in clinical trial NCT03764488 (A Study to Evaluate Safety, Tolerability, and Distribution of a Microdose of Radiolabeled BIIB067 (99mTc-MAG3-BIIB067) Co-administered With BIIB067 to Healthy Adults). Cobitolimod Cobitolimod is under investigation in clinical trial NCT03178669 (The Efficacy of Cobitolimod in Patients With Moderate to Severe Active Ulcerative Colitis). Danvatirsen Danvatirsen is under investigation in clinical trial NCT03334617 (Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy.). Imetelstat Imetelstat is under investigation in clinical trial NCT01916187 (Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma). Bazlitoran Bazlitoran is under investigation in clinical trial NCT02092909 (Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia). Mongersen Mongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult... GTI-2040 GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors). NUC-1031 NUC-1031 is under investigation in clinical trial NCT03610100 (Acelarin First Line Randomised Pancreatic Study). ARC-19499 ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients). Radavirsen Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza). Aganirsen Aganirsen is under investigation in clinical trial NCT02947867 (Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG). Cenersen Cenersen is under investigation in clinical trial NCT02243124 (A Study of Aezea® (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome (MDS)). Golodirsen A drug used to treat certain mutations that cause Duchenne muscular dystrophy (DMD). Diquafosol A medication indicated to treat dry eyes associated with keratoconjunctival disorders. Anivamersen Anivamersen is under investigation in clinical trial NCT01848106 (A Study to Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI). Eluforsen Eluforsen is under investigation in clinical trial NCT02532764 (Dose Escalation Study of QR-010 in Homozygous ΔF508 Cystic Fibrosis Patients). ISIS 2503 ISIS 2503 is under investigation in clinical trial NCT00004193 (ISIS 2503 in Treating Patients With Metastatic And/or Locally Recurrent Colorectal Cancer). ISIS 104838 ISIS 104838 is under investigation in clinical trial NCT00048321 (ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid Arthritis). Pelacarsen Pelacarsen is under investigation in clinical trial NCT03070782 (Phase 2 Study of ISIS 681257 (Akcea-apo(a)-lrx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease). Rintatolimod Not Annotated AT-527 Not Available - Drugs & Drug Targets