Chemically-Induced Disorders

Name
Chemically-Induced Disorders
Accession Number
DBCAT000397
Description

Disorders caused by the intentional or unintentional ingestion or exposure to chemical substances such as PHARMACEUTICAL PREPARATIONS; NOXAE; and PESTICIDES.

Drugs
DrugDrug Description
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
VoriconazoleA triazole compound used to treat fungal infections.
RifampinAn antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.
MiconazoleAn azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.
PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
Drugs & Drug Targets
DrugTargetType
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineATP-dependent translocase ABCB1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineOrganic cation/carnitine transporter 2transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineOrganic anion transporter 3transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineFlavin-containing monooxygenase 3enzyme
CimetidineFlavin-containing monooxygenase 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
CimetidineAlbumincarrier
RitonavirPol polyproteintarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirATP-dependent translocase ABCB1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirATP-binding cassette sub-family C member 2transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirAlbumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter
RitonavirGag-Pol polyproteintarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 2-alphatarget
CiprofloxacinCytochrome P450 1A2enzyme
CiprofloxacinCytochrome P450 3A4enzyme
CiprofloxacinCytochrome P450 3A5enzyme
CiprofloxacinCytochrome P450 3A7enzyme
CiprofloxacinATP-dependent translocase ABCB1transporter
CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Btarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug resistance protein MdtKtarget
CiprofloxacinGyrase Atarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug and toxin extrusion protein 1transporter
CiprofloxacinMultidrug and toxin extrusion protein 2transporter
CiprofloxacinAlbumincarrier
CiprofloxacinThymidylate synthasetarget
CiprofloxacinDNA gyrase subunit Btarget
VoriconazoleCytochrome P450 2C19enzyme
VoriconazoleCytochrome P450 3A4enzyme
VoriconazoleCytochrome P450 2C9enzyme
VoriconazoleFlavin-containing monooxygenase 1enzyme
VoriconazoleFlavin-containing monooxygenase 3enzyme
VoriconazoleCytochrome P450 3A5enzyme
VoriconazoleCytochrome P450 3A7enzyme
VoriconazoleProstaglandin G/H synthase 1enzyme
VoriconazoleLanosterol 14-alpha demethylasetarget
VoriconazoleCytochrome P450 2B6enzyme
RifampinNuclear receptor subfamily 1 group I member 2target
RifampinCytochrome P450 3A4enzyme
RifampinCytochrome P450 1A2enzyme
RifampinCytochrome P450 2C8enzyme
RifampinUDP-glucuronosyltransferase 1A1enzyme
RifampinCytochrome P450 2C9enzyme
RifampinCytochrome P450 2B6enzyme
RifampinCytochrome P450 2C19enzyme
RifampinATP-binding cassette sub-family C member 3transporter
RifampinATP-binding cassette sub-family C member 5transporter
RifampinATP-dependent translocase ABCB1transporter
RifampinATP-binding cassette sub-family C member 2transporter
RifampinSolute carrier organic anion transporter family member 2B1transporter
RifampinBile salt export pumptransporter
RifampinMultidrug resistance-associated protein 1transporter
RifampinSolute carrier organic anion transporter family member 1A2transporter
RifampinSolute carrier organic anion transporter family member 1B3transporter
RifampinSolute carrier family 22 member 7transporter
RifampinSolute carrier organic anion transporter family member 1B1transporter
RifampinCytochrome P450 2A6enzyme
RifampinCytochrome P450 2E1enzyme
RifampinCytochrome P450 3A43enzyme
RifampinCytochrome P450 3A7enzyme
RifampinSolute carrier family 22 member 6transporter
RifampinOrganic anion transporter 3transporter
RifampinUDP-glucuronosyltransferase 1A9enzyme
RifampinCytochrome P450 3A5enzyme
RifampinAlbumincarrier
Rifampinalpha1-acid glycoproteincarrier
RifampinDNA-directed RNA polymerase subunit betatarget
MiconazoleCytochrome P450 2C9enzyme
MiconazoleCytochrome P450 2D6enzyme
MiconazoleCytochrome P450 3A4enzyme
MiconazoleATP-dependent translocase ABCB1transporter
MiconazoleLanosterol 14-alpha demethylasetarget
MiconazoleNitric oxide synthase 3target
MiconazoleNitric oxide synthase, inducibletarget
MiconazoleCytochrome P450 11B1, mitochondrialenzyme
MiconazoleCytochrome P450 2A6enzyme
MiconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C19enzyme
MiconazoleCytochrome P450 2E1enzyme
MiconazoleNuclear receptor subfamily 1 group I member 2target
MiconazoleLanosterol 14-alpha demethylaseenzyme
MiconazoleAromataseenzyme
MiconazoleCalcium-activated potassium channeltarget
MiconazoleVoltage-gated Potassium Channelstarget
MiconazoleInward rectifier potassium channeltarget
MiconazoleVoltage gated L-type calcium channeltarget
MiconazoleAlbumincarrier
MiconazoleCytochrome P450 2C8enzyme
PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
PhenobarbitalCytochrome P450 2C19enzyme
PhenobarbitalCytochrome P450 2C9enzyme
PhenobarbitalCytochrome P450 2B6enzyme
PhenobarbitalCytochrome P450 2C8enzyme
PhenobarbitalCytochrome P450 1A2enzyme
PhenobarbitalCytochrome P450 3A4enzyme
PhenobarbitalATP-binding cassette sub-family C member 3transporter
PhenobarbitalBile salt export pumptransporter
PhenobarbitalATP-dependent translocase ABCB1transporter
PhenobarbitalMultidrug resistance-associated protein 1transporter
PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
PhenobarbitalATP-binding cassette sub-family C member 2transporter
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
PhenobarbitalGlutamate receptor 2target
PhenobarbitalGlutamate receptor ionotropic, kainate 2target
PhenobarbitalCytochrome P450 2A6enzyme
PhenobarbitalCytochrome P450 2E1enzyme
PhenobarbitalCytochrome P450 3A5enzyme
PhenobarbitalCytochrome P450 1A1enzyme
PhenobarbitalCytochrome P450 2C18enzyme
PhenobarbitalCytochrome P450 3A7enzyme
PhenobarbitalCytochrome P450 4B1enzyme
PhenobarbitalNMDA receptortarget
PhenobarbitalNuclear receptor subfamily 1 group I member 2target
PhenobarbitalUDP-glucuronosyltransferase 1A1enzyme
PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1A1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1A3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1A9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilAlbumincarrier
GemfibrozilOrganic anion transporter 3target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
GemfibrozilLipoprotein lipasetarget