14-alpha Demethylase Inhibitors

Name
14-alpha Demethylase Inhibitors
Accession Number
DBCAT000488
Description

Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.

Drugs
DrugDrug Description
FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
VoriconazoleA triazole compound used to treat fungal infections.
MiconazoleAn azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.
TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
ItraconazoleA triazole antifungal agent used to treat various fungal infections, such as blastomycosis and onychomycosis.
EconazoleA topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
OteseconazoleAn azole antifungal used to prevent recurrent vulvovaginal candidiasis in females who are not of reproductive potential.
Drugs & Drug Targets
DrugTargetType
FluconazoleCytochrome P450 3A4enzyme
FluconazoleCytochrome P450 2C9enzyme
FluconazoleCytochrome P450 2C19enzyme
FluconazoleP-glycoprotein 1transporter
FluconazoleCytochrome P450 51target
FluconazoleCytochrome P450 3A5enzyme
VoriconazoleCytochrome P450 2C19enzyme
VoriconazoleCytochrome P450 3A4enzyme
VoriconazoleCytochrome P450 2C9enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
VoriconazoleCytochrome P450 3A5enzyme
VoriconazoleCytochrome P450 3A7enzyme
VoriconazoleProstaglandin G/H synthase 1enzyme
VoriconazoleCytochrome P450 51target
VoriconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C9enzyme
MiconazoleCytochrome P450 2D6enzyme
MiconazoleCytochrome P450 3A4enzyme
MiconazoleP-glycoprotein 1transporter
MiconazoleCytochrome P450 51target
MiconazoleNitric oxide synthase, endothelialtarget
MiconazoleNitric oxide synthase, inducibletarget
MiconazoleCytochrome P450 11B1, mitochondrialenzyme
MiconazoleCytochrome P450 2A6enzyme
MiconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C19enzyme
MiconazoleCytochrome P450 2E1enzyme
MiconazoleNuclear receptor subfamily 1 group I member 2target
MiconazoleLanosterol 14-alpha demethylaseenzyme
MiconazoleCytochrome P450 19A1enzyme
MiconazoleCalcium-activated potassium channeltarget
MiconazoleVoltage-gated Potassium Channelstarget
MiconazoleInward rectifier potassium channeltarget
MiconazoleVoltage gated L-type calcium channeltarget
MiconazoleSerum albumincarrier
MiconazoleCytochrome P450 2C8enzyme
TioconazoleLanosterol 14-alpha demethylasetarget
TioconazoleCytochrome P450 19A1enzyme
TioconazoleCytochrome P450 2C19enzyme
TioconazoleCytochrome P450 2E1enzyme
TioconazoleCytochrome P450 3A4enzyme
TioconazoleCytochrome P450 51target
KetoconazoleCytochrome P450 3A4enzyme
KetoconazoleCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 2C19enzyme
KetoconazoleCytochrome P450 3A5enzyme
KetoconazoleCytochrome P450 1A2enzyme
KetoconazoleCytochrome P450 2C8enzyme
KetoconazoleCytochrome P450 1A1enzyme
KetoconazoleCytochrome P450 2D6enzyme
KetoconazoleBile salt export pumptransporter
KetoconazoleP-glycoprotein 1transporter
KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
KetoconazoleCytochrome P450 1B1enzyme
KetoconazoleCytochrome P450 2A6enzyme
KetoconazoleCytochrome P450 2B6enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleAndrogen receptortarget
KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
KetoconazoleSteroid 21-hydroxylasetarget
KetoconazolePotassium voltage-gated channel subfamily H member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 3target
KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
KetoconazoleCytochrome P450 4F12enzyme
KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
KetoconazoleSerum albumincarrier
KetoconazoleSex hormone-binding globulincarrier
KetoconazoleCytochrome P450 19A1enzyme
KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleP-glycoprotein 1transporter
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
ItraconazoleCytochrome P450 3A Subfamilyenzyme
ItraconazoleATP-binding cassette sub-family G member 2transporter
ItraconazoleSerum albumincarrier
ItraconazoleLanosterol 14-alpha demethylasetarget
EconazoleCytochrome P450 19A1enzyme
EconazoleCytochrome P450 2E1enzyme
EconazoleCytochrome P450 3A4enzyme
EconazoleCytochrome P450 51target
EconazoleNuclear receptor subfamily 1 group I member 2target
PosaconazoleCytochrome P450 3A4enzyme
PosaconazoleP-glycoprotein 1transporter
PosaconazoleCytochrome P450 51target
OteseconazoleCytochrome P450 51target
OteseconazoleATP-binding cassette sub-family G member 2transporter