Econazole is a topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. A broad spectrum antimycotic with some action against Gram positive bacteria.
- Mechanism
- Curator reviewed
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
- Primary indication
- For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of...Curator reviewed · 20 structured indications
- Formula / weight
- C18H15Cl3N2O · 381.684 g/mol (avg)
- First approval
- Canada, 2004 · United States, 1982
- Brand names
Resolves to
LEZWWPYKPKIXLL-UHFFFAOYSA-NSMILESClC1=CC=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Econazole, and which of those have an active Phase 3 trial?
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