Purinergic P1 Receptor Antagonists

Name
Purinergic P1 Receptor Antagonists
Accession Number
DBCAT000508
Description

Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.

Drugs
DrugDrug Description
TheophyllineA xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
EnprofyllineUsed in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
AminophyllineA bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
NaxifyllineInvestigated for use/treatment in congestive heart failure.
VipadenantInvestigated for use/treatment in parkinson's disease.
IstradefyllineA selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease.
8-cyclopentyl-1,3-dipropylxanthineCPX has been used in trials studying the treatment of Cystic Fibrosis.
Drugs & Drug Targets
DrugTargetType
TheophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
TheophyllineAdenosine receptor A2btarget
TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
TheophyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
TheophyllineAdenosine receptor A1target
TheophyllineAdenosine receptor A2atarget
TheophyllineCytochrome P450 1A2enzyme
TheophyllineAdenosine deaminaseenzyme
TheophyllineCytochrome P450 2E1enzyme
TheophyllineCytochrome P450 3A4enzyme
TheophyllineSolute carrier family 22 member 7transporter
TheophyllineCytochrome P450 1A1enzyme
TheophyllineCytochrome P450 1B1enzyme
TheophyllineCytochrome P450 2D6enzyme
TheophyllineHistone deacetylase 2target
TheophyllineCopine-1target
TheophyllineMinor histocompatibility antigen H13target
TheophyllineNodal modulator 1target
TheophyllinePoly [ADP-ribose] polymerase 1target
TheophyllineProtein RIC-3target
TheophyllineTubulin monoglycylase TTLL3target
EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
EnprofyllineAdenosine receptor A2btarget
EnprofyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
EnprofyllineAdenosine receptor A1target
EnprofyllineAdenosine receptor A2atarget
EnprofyllineAdenosine receptor A3target
AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AminophyllineAdenosine receptor A3target
AminophyllineAdenosine receptor A1target
AminophyllineCytochrome P450 1A2enzyme
AminophyllineCytochrome P450 2E1enzyme
AminophyllineCytochrome P450 3A4enzyme
AminophyllineHistone deacetylase 2target
NaxifyllineAdenosine receptor A1target
IstradefyllineCytochrome P450 1A1enzyme
IstradefyllineCytochrome P450 3A4enzyme
IstradefyllineCytochrome P450 3A5enzyme
IstradefyllineCytochrome P450 1A2enzyme
IstradefyllineCytochrome P450 2B6enzyme
IstradefyllineCytochrome P450 2C8enzyme
IstradefyllineCytochrome P450 2C9enzyme
IstradefyllineCytochrome P450 2C18enzyme
IstradefyllineCytochrome P450 2D6enzyme
IstradefyllineCytochrome P450 3A Subfamilyenzyme
IstradefyllineP-glycoprotein 1transporter
IstradefyllineAdenosine receptor A2atarget
IstradefyllineAdenosine receptor A1target
IstradefyllineSerum albumincarrier
Istradefyllinealpha1-acid glycoproteincarrier
IstradefyllineATP-binding cassette sub-family G member 2transporter
IstradefyllineSolute carrier organic anion transporter family member 1B1transporter
IstradefyllineSolute carrier organic anion transporter family member 1B3transporter
IstradefyllineSolute carrier family 22 member 6transporter
IstradefyllinePOU domain, class 2, transcription factor 2transporter
IstradefyllineMultidrug and toxin extrusion protein 1transporter
IstradefyllineMultidrug and toxin extrusion protein 2transporter