Selective Estrogen Receptor Modulators
- Name
- Selective Estrogen Receptor Modulators
- Accession Number
- DBCAT000918
- Description
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
- ATC Classification
- Drugs
Drug Drug Description Afimoxifene For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring. Bazedoxifene A selective estrogen receptor modulator (SERM) used to treat moderate to severe vasomotor symptoms in menopause and osteoporosis alone or in combination with conjugated estrogens. Clomifene A medication used to induce ovulation. Cyclofenil Not Annotated Enclomiphene Not Annotated Fulvestrant An estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. Lasofoxifene Investigated for use/treatment in postmenopausal osteoporosis to reduce the risk of both vertebral and novertebral fractures, as well as address other postmenopausal conditions, including reduction in risk of breast cancer... Ormeloxifene A selective estrogen receptor modulator used as a non-hormonal, non-steroidal oral contraceptive. Ospemifene A non-hormonal estrogen receptor modulator (SERM) used to treat moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. Raloxifene A selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women. Tamoxifen A selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women. Toremifene A first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers.