Fatty Acid Synthesis Inhibitors

Name
Fatty Acid Synthesis Inhibitors
Accession Number
DBCAT001001
Description

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some ANTINEOPLASTIC AGENTS and ANTI-OBESITY AGENTS and of some ANTI-INFECTIVE AGENTS which interfere with CELL WALL and CELL MEMBRANE formation.

Drugs
DrugDrug Description
EthionamideA second line antitubercular agent used to treat tuberculosis when other treatments have failed.
IsoniazidAn antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.
CeruleninFor use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animals
TriclosanAn antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.
PlatensimycinNot Available
Drugs & Drug Targets
DrugTargetType
EthionamideCatalase-peroxidasetarget
EthionamideEnoyl-[acyl-carrier-protein] reductase [NADH]target
IsoniazidCatalase-peroxidasetarget
IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]target
IsoniazidCytochrome P450 2E1enzyme
IsoniazidCytochrome P450 1A2enzyme
IsoniazidCytochrome P450 2C9enzyme
IsoniazidCytochrome P450 2D6enzyme
IsoniazidCytochrome P450 2C19enzyme
IsoniazidArylamine N-acetyltransferase 2enzyme
IsoniazidArylamine N-acetyltransferaseenzyme
IsoniazidCytochrome P450 2A6enzyme
IsoniazidCytochrome P450 2C8enzyme
IsoniazidCytochrome P450 2C8target
IsoniazidCytochrome P450 1A2target
IsoniazidCytochrome P450 3A4target
IsoniazidCytochrome P450 2C19target
IsoniazidDihydrofolate reductasetarget
IsoniazidSerum albumincarrier
Cerulenin3-oxoacyl-[acyl-carrier-protein] synthase 3target
Cerulenin3-oxoacyl-[acyl-carrier-protein] synthase 2target
Cerulenin3-oxoacyl-[acyl-carrier-protein] synthase 1target
CeruleninFatty acid synthasetarget
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH] FabItarget
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADH]target
TriclosanEnoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget
TriclosanNuclear receptor subfamily 1 group I member 2target
TriclosanAndrogen receptortarget
TriclosanNuclear receptor subfamily 1 group I member 3target
TriclosanPeroxisome proliferator-activated receptor gammatarget
TriclosanThyroid peroxidasetarget
Platensimycin3-oxoacyl-[acyl-carrier-protein] synthase 2target