Lactams, Macrocyclic

Name
Lactams, Macrocyclic
Accession Number
DBCAT001006
Description

LACTAMS forming compounds with a ring size of approximately 1-3 dozen atoms.

Drugs
DrugDrug Description
Coltuximab ravtansineInvestigated for use/treatment in lymphoma (non-hodgkin's).
Mirvetuximab SoravtansineMirvetuximab Soravtansine has been used in trials studying the treatment of Ovarian cancer, Endometrial Cancer, Fallopian tube cancer, Epithelial Ovarian Cancer, and Primary Peritoneal Cancer, among others.
RifamycinAn antibacterial used to treat traveler's diarrhea.
Drugs & Drug Targets
DrugTargetType
Coltuximab ravtansineB-lymphocyte antigen CD19target
Coltuximab ravtansineCytochrome P450 3A4enzyme
Mirvetuximab SoravtansineCytochrome P450 3A4enzyme
RifamycinCytochrome P450 3A4enzyme
RifamycinCytochrome P450 2C19enzyme
RifamycinCytochrome P450 2B6enzyme
RifamycinCytochrome P450 2C8enzyme
RifamycinCytochrome P450 2C9enzyme
RifamycinSolute carrier organic anion transporter family member 1A2transporter
RifamycinSolute carrier organic anion transporter family member 1B1transporter
RifamycinSolute carrier organic anion transporter family member 1B3transporter
RifamycinSolute carrier organic anion transporter family member 2A1transporter
RifamycinSolute carrier organic anion transporter family member 2B1transporter
RifamycinSerum albumincarrier
RifamycinDNA-directed RNA polymerase subunit betatarget
RifamycinDNA-directed RNA polymerase subunit alphatarget
RifamycinDNA-directed RNA polymerase subunit beta'target
RifamycinMultidrug and toxin extrusion protein 1transporter
RifamycinCytochrome P450 1A2enzyme
RifamycinP-glycoprotein 1transporter
RifamycinCytochrome P450 2D6enzyme