Neprilysin, antagonists & inhibitors
- Neprilysin, antagonists & inhibitors
- Accession Number
Drug Drug Description Candoxatril Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor. Daglutril Investigated for use/treatment in congestive heart failure and hypertension. Sacubitril A neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Candoxatrilat A dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,... Racecadotril An anti-secretory enkephalinase inhibitor useful in the treatment of diarrhea.
- Drugs & Drug Targets
Drug Target Type Candoxatril Neprilysin target Candoxatril Angiotensin-converting enzyme target Daglutril Neprilysin target Sacubitril Neprilysin target Sacubitril Solute carrier organic anion transporter family member 1B1 transporter Sacubitril Solute carrier organic anion transporter family member 1B3 transporter Candoxatrilat Neprilysin target