Candoxatrilat

DB11623ExperimentalSmall molecule

A dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,... A potent inhibitor of neutral endopeptidase (NEP, neprilysin, EC 3.4.24.11), it is used as its 2,3-dihydro-1H-inden-5-yl ester prodrug in the treatment of chronic heart failure.

Chemical structure of Candoxatrilat
Mechanism
Curator reviewed
Formula / weight
C20H33NO7 · 399.484 g/mol (avg)
Also known as
Candoxatrilate
Code names
UK-73,967

Resolves to

Compound
UNII7WU8BZ90THCAS123122-54-3ChEMBLCHEMBL434492ChEBI3354PubChem443380KEGGD03349
Structure
InChIKeyACZWIDANLCXHBM-HRCADAONSA-NSMILESCOCCOC[C@H](CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(O)=O)C(O)=O
Targets
P08473MME

What you can answer from here — as of February 21, 2021

1Protein targetEach mapped to UniProt, with action and pharmacological action
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5+ReferencesStructured and connected to the statements they support
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