This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Racecadotril is an anti-secretory enkephalinase inhibitor useful in the treatment of diarrhea.
- Generic Name
- Racecadotril
- DrugBank Accession Number
- DB11696
- Background
Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Racecadotril (DB11696)
- Weight
- Average: 385.48
Monoisotopic: 385.134779399 - Chemical Formula
- C21H23NO4S
- Synonyms
- Racecadotril
- Racecadotrilo
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- A07XA04 — Racecadotril
- Drug Categories
- Alimentary Tract and Metabolism
- Amino Acids
- Amino Acids, Peptides, and Proteins
- Amino Acids, Sulfur
- Antidiarrheals
- Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents
- Enzyme Inhibitors
- Gastrointestinal Agents
- N-substituted Glycines
- Neprilysin, antagonists & inhibitors
- Protease Inhibitors
- Sulfur Compounds
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- N-acyl-alpha amino acids and derivatives
- Alternative Parents
- Alpha amino acid esters / Benzyloxycarbonyls / Thioesters / Carboxylic acid esters / Carbothioic S-esters / Sulfenyl compounds / Propargyl-type 1,3-dipolar organic compounds / Monocarboxylic acids and derivatives / Carboximidic acids / Organopnictogen compounds show 4 more
- Substituents
- Alpha-amino acid ester / Aromatic homomonocyclic compound / Benzenoid / Benzyloxycarbonyl / Carbonyl group / Carbothioic s-ester / Carboximidic acid / Carboximidic acid derivative / Carboxylic acid ester / Hydrocarbon derivative show 15 more
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 76K53XP4TO
- CAS number
- 81110-73-8
- InChI Key
- ODUOJXZPIYUATO-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)
- IUPAC Name
- benzyl 2-{2-[(acetylsulfanyl)methyl]-3-phenylpropanamido}acetate
- SMILES
- CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC1=CC=CC=C1
References
- General References
- EMC Summary of Product Characteristics: Hidrasec (racecadotril) granules for oral suspension [Link]
- External Links
- PubChem Compound
- 107751
- PubChem Substance
- 347828061
- ChemSpider
- 96913
- 16738
- ChEBI
- 91508
- ChEMBL
- CHEMBL2103772
- Wikipedia
- Racecadotril
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Acute Diarrhea / Acute Gastroenteritis 1 3 Completed Treatment Diarrhea 2 3 Completed Treatment Infantile Diarrhea 1 1 Completed Not Available Healthy Male Volunteers 1 1 Completed Basic Science Antidiarrheals 1 1 Completed Basic Science Diarrhea 1 1 Completed Treatment Acute Watery Diarrhea 1 Not Available Not Yet Recruiting Treatment Diarrhea 1 Not Available Recruiting Basic Science Acute Respiratory Distress Syndrome (ARDS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Powder, for suspension Oral 30 mg Capsule Oral Granule, for suspension Oral Powder Oral 30 mg Powder, for suspension Oral 6 mg Granule, for suspension Oral 30.00 mg Powder, for suspension Oral 10 mg Granule, for suspension Oral 10.00 mg Powder, for solution Oral 10 mg Granule Oral 30 mg Tablet Oral 10 mg Tablet Oral 30 mg Granule Oral 10 mg Capsule, coated Oral 100 mg Tablet, film coated Tablet, film coated 175 MG Capsule Oral 100 mg Powder Oral 6 mg/1sachet Powder Oral 30 mg/1sachet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00176 mg/mL ALOGPS logP 2.72 ALOGPS logP 3.17 Chemaxon logS -5.3 ALOGPS pKa (Strongest Acidic) 12.6 Chemaxon pKa (Strongest Basic) -2.1 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 72.47 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 106 m3·mol-1 Chemaxon Polarizability 40.84 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available MS/MS Spectrum - , positive LC-MS/MS splash10-014l-1295000000-b84f3c2b1498077b2476 MS/MS Spectrum - , positive LC-MS/MS splash10-014l-1395000000-c4e257557748aee5583a
Drug created at October 20, 2016 20:40 / Updated at May 07, 2021 21:07