Fluorouracil and prodrugs

DBCAT001268Pharmacologic classL01BC02

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. A DrugBank category of 7 drugs. 4 of them are approved.

ATC classification: L — ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 — ANTINEOPLASTIC AGENTS
L01B — ANTIMETABOLITES
L01BC — Pyrimidine analogues
L01BC02 — fluorouracil
Also known as: 5 Fluorouracil · 5 Fluorouracil biosyn · 5 FU · 5 FU Lederle · 5 FU medac
Drugs: 5-fluorouridine
Capecitabine
Doxifluridine
Flucytosine
Fluorouracil
Tegafur
Uracil

What you can answer from here — as of December 12, 2019

7DrugsEach linked to its full drug card

Listed above

15Drug targetsEvery drug–target pair in the class, with bond type

901Marketed productsAcross the regions we cover, with dosage forms and routes

7Routes of administrationHow the drugs in this class are given

Which targets do Fluorouracil and prodrugs share, and which companies have late-stage candidates in this class?

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