Antiarrhythmics, Class Ib

Antiarrhythmics, Class Ib
Accession Number
DBCAT002278  (DBCAT003656)

Small reduction in phase 0 slope; reduce APD (atrial premature depolarization); decrease ERP (effective refractory period).

ATC Classification
DrugDrug Description
MexiletineA class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment.
TocainideAn orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias.
AprindineAprindine is a cardiac depressant used in arrhythmias.
LidocaineA local anesthetic used in a wide variety of superficial and invasive procedures.
Drugs & Drug Targets
MexiletineSodium channel protein type 5 subunit alphatarget
MexiletineCytochrome P450 1A2enzyme
MexiletineCytochrome P450 2D6enzyme
MexiletineCytochrome P450 2B6enzyme
MexiletineCytochrome P450 2E1enzyme
MexiletineCytochrome P450 3A4enzyme
MexiletineAryl hydrocarbon receptortarget
TocainideSodium channel protein type 5 subunit alphatarget
TocainideSerum albumincarrier
TocainideCytochrome P450 1A2enzyme
AprindineAlpha-1-acid glycoprotein 1carrier
AprindineSodium channel protein type 5 subunit alphatarget
AprindineCytochrome P450 2D6enzyme
LidocaineSodium channel protein type 5 subunit alphatarget
LidocaineSodium channel protein type 10 subunit alphatarget
LidocaineEpidermal growth factor receptortarget
LidocaineSodium channel protein type 9 subunit alphatarget
LidocaineCytochrome P450 1A2enzyme
LidocaineCytochrome P450 2D6enzyme
LidocaineCytochrome P450 3A4enzyme
LidocaineCytochrome P450 3A5enzyme
LidocaineCytochrome P450 3A7enzyme
LidocaineSolute carrier family 22 member 5transporter
LidocaineP-glycoprotein 1transporter
LidocaineCytochrome P450 2A6enzyme
LidocaineCytochrome P450 2B6enzyme
LidocaineCytochrome P450 2C8enzyme
LidocaineCytochrome P450 2C9enzyme
LidocaineSodium channel protein type 4 subunit alphatarget
LidocaineAlpha-1-acid glycoprotein 1target
LidocaineAlpha-1-acid glycoprotein 2target