Arteriolar Smooth Muscle, Agents Acting On

Name
Arteriolar Smooth Muscle, Agents Acting On
Accession Number
DBCAT002307
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
NitroprussideA direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure.
MinoxidilAn antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage.
EndralazineNot Annotated
CadralazineNot Annotated
DiazoxideA non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions.
HydralazineAn antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia .
PinacidilPinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood...
DihydralazineDihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).
Drugs & Drug Targets
DrugTargetType
NitroprussideAtrial natriuretic peptide receptor 1target
NitroprussideCytochrome P450 1A1enzyme
MinoxidilATP-sensitive inward rectifier potassium channel 1target
MinoxidilProstaglandin G/H synthase 1target
MinoxidilRenintarget
MinoxidilUDP-glucuronosyltransferase 1-1enzyme
DiazoxideCarbonic anhydrase 1target
DiazoxideCarbonic anhydrase 2target
DiazoxideCalcium-activated potassium channel subunit alpha-1target
DiazoxideSodium/potassium-transporting ATPase subunit alpha-1target
DiazoxideATP-sensitive inward rectifier potassium channel 11target
DiazoxideGlutamine synthetaseenzyme
HydralazineMembrane primary amine oxidasetarget
HydralazineProlyl 4-hydroxylase subunit alpha-1target
HydralazineCytochrome P450 3A4enzyme
HydralazineSerum albumincarrier
HydralazineHypoxia-inducible factor 1-alphatarget
PinacidilCytochrome P450 3A4enzyme
DihydralazineCytochrome P450 1A2enzyme