Cytochrome P-450 CYP2C19 Inhibitors (moderate)

Cytochrome P-450 CYP2C19 Inhibitors (moderate)
Accession Number

Not Available

DrugDrug Description
SertralineA selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions.
EfavirenzA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
ArmodafinilA stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder.
Eslicarbazepine acetateAn anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy.
AbirateroneAn antiandrogen used in the treatment of prostate cancer.
ZucapsaicinA topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients.
TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
CisaprideA medication used to treat heartburn associated with GERD.
ZafirlukastA leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma.
Drugs & Drug Targets
SertralineSodium-dependent serotonin transportertarget
SertralineCytochrome P450 2B6enzyme
SertralineCytochrome P450 2C19enzyme
SertralineCytochrome P450 2C9enzyme
SertralineCytochrome P450 2D6enzyme
SertralineSodium-dependent dopamine transportertarget
SertralineCYP2B proteinenzyme
SertralineCytochrome P450 3A4enzyme
SertralineAmine oxidase [flavin-containing] Benzyme
SertralineAmine oxidase [flavin-containing] Aenzyme
SertralineP-glycoprotein 1transporter
SertralineSerum albumincarrier
SertralineSigma receptortarget
SertralineSodium-dependent noradrenaline transportertarget
SertralineEquilibrative nucleoside transporter 4target
SertralineCytochrome P450 2E1enzyme
EfavirenzCytochrome P450 2B6enzyme
EfavirenzCytochrome P450 3A4enzyme
EfavirenzCytochrome P450 2C19enzyme
EfavirenzCytochrome P450 2C9enzyme
EfavirenzCytochrome P450 1A2enzyme
EfavirenzCytochrome P450 2D6enzyme
EfavirenzReverse transcriptase/RNaseHtarget
EfavirenzCytochrome P450 2C8enzyme
EfavirenzSerum albumincarrier
EfavirenzCytochrome P450 3A5enzyme
EfavirenzCytochrome P450 3A7enzyme
EfavirenzUDP-glucuronosyltransferase 1-1enzyme
EfavirenzBile salt export pumptransporter
EfavirenzSolute carrier family 22 member 1transporter
ArmodafinilCytochrome P450 2C19enzyme
ArmodafinilCytochrome P450 3A4enzyme
ArmodafinilCytochrome P450 1A2enzyme
ArmodafinilCytochrome P450 2B6enzyme
ArmodafinilCytochrome P450 3A5enzyme
ArmodafinilCytochrome P450 2C9enzyme
ArmodafinilSodium-dependent dopamine transportertarget
Eslicarbazepine acetateCytochrome P450 2C19enzyme
Eslicarbazepine acetateCytochrome P450 3A4enzyme
Eslicarbazepine acetateP2X purinoceptor 4target
Eslicarbazepine acetateUDP-glucuronosyltransferase 1-1enzyme
AbirateroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
AbirateroneSerum albumincarrier
AbirateroneAlpha-1-acid glycoprotein 1carrier
AbirateroneCytochrome P450 3A4enzyme
AbirateroneBile salt sulfotransferaseenzyme
AbirateroneMultidrug resistance-associated protein 1transporter
AbirateroneCytochrome P450 2D6enzyme
AbirateroneCytochrome P450 2C8enzyme
AbirateroneCytochrome P450 1A2enzyme
AbirateroneCytochrome P450 2C19enzyme
AbirateroneCytochrome P450 2C9enzyme
ZucapsaicinTransient receptor potential cation channel subfamily V member 1target
ZucapsaicinCytochrome P450 1A2enzyme
ZucapsaicinCytochrome P450 2C19enzyme
ZucapsaicinCytochrome P450 2C9enzyme
ZucapsaicinCytochrome P450 2E1enzyme
TiclopidineP2Y purinoceptor 12target
TiclopidineCytochrome P450 2C19enzyme
TiclopidineCytochrome P450 2B6enzyme
TiclopidineCytochrome P450 2C9enzyme
TiclopidineCytochrome P450 2D6enzyme
TiclopidineCytochrome P450 1A2enzyme
TiclopidineCytochrome P450 2C8enzyme
TiclopidineCytochrome P450 2E1enzyme
Cisapride5-hydroxytryptamine receptor 4target
Cisapride5-hydroxytryptamine receptor 3Atarget
CisapridePotassium voltage-gated channel subfamily H member 2target
Cisapride5-hydroxytryptamine receptor 2Atarget
CisaprideCytochrome P450 3A4enzyme
CisaprideCytochrome P450 3A5enzyme
CisaprideCytochrome P450 3A7enzyme
CisaprideCytochrome P450 2A6enzyme
CisaprideCytochrome P450 2B6enzyme
CisaprideCytochrome P450 2C19enzyme
CisaprideCytochrome P450 2C8enzyme
CisaprideCytochrome P450 2C9enzyme
CisaprideCytochrome P450 2D6enzyme
ZafirlukastCysteinyl leukotriene receptor 1target
ZafirlukastCytochrome P450 2C9enzyme
ZafirlukastCytochrome P450 2C8enzyme
ZafirlukastProstaglandin G/H synthase 1enzyme
ZafirlukastCytochrome P450 3A4enzyme
ZafirlukastCytochrome P450 1A2enzyme
ZafirlukastCytochrome P450 2C19enzyme
ZafirlukastATP-binding cassette sub-family G member 2transporter
ZafirlukastCytochrome P450 2D6enzyme