Cytochrome P-450 CYP2C19 Inhibitors
- Name
- Cytochrome P-450 CYP2C19 Inhibitors
- Accession Number
- DBCAT000403 (DBCAT004211)
- Description
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19.
- Drugs
Drug Drug Description Abiraterone An antiandrogen used in the treatment of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer. Alpelisib Alpelisib is indicated in combination with fulvestrant to treat postmenopausal women, and men, with advanced or metastatic breast cancer. This cancer must be hormone receptor (HR)-positive, human epidermal growth factor... Aminophenazone An analgesic drug used to treat acute migraine attacks in combination with ergotamine and caffeine. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Amlodipine A calcium channel blocker used to treat hypertension and angina. Amprenavir A protease inhibitor used to treat HIV infection. Angelica sinensis root Angelica sinensis root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. Antipyrine An antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Aprocitentan An endothelin receptor antagonist used for the treatment of uncontrolled hypertension in patients inadequately controlled on other treatments. Armodafinil A stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. Artenimol For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941. Asciminib An inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation. Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Avasimibe Investigated for use/treatment in peripheral vascular disease. Azelastine A histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis. Belumosudil An oral inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK) used in the treatment of chronic graft-versus-host disease (GVHD). Benzbromarone A uricosuric agent which is taken daily for the prevention of gout flares. Besigomsin Besigomsin is a small molecule drug. Besigomsin has a monoisotopic molecular weight of 416.18 Da. Bicalutamide An androgen receptor inhibitor used to treat Stage D2 metastatic carcinoma of the prostate. Bortezomib A proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. Brincidofovir An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping. Cenobamate A small molecule drug indicated to treat partial onset seizures in adults. Chloramphenicol A broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Cisapride A medication used to treat heartburn associated with GERD. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Clascoterone An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. Clevidipine A dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Clinafloxacin Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of... Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Curcumin sulfate No approved therapeutic indications. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Delavirdine A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection. Dexlansoprazole A proton pump inhibitor used to treat erosive esophagitis, heartburn, and gastroesophageal reflux disease (GERD). Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Dimethyl sulfoxide A reversible mitogen-activated extracellular signal-regulated kinase-1 (MEK1) and MEK2 inhibitor used to treat certain types of melanoma, metastatic non-small cell lung cancer, and locally advanced or metastatic anaplastic thyroid cancer. Dordaviprone A protease inhibitor used to treat diffuse midline glioma with a H3 K27M mutation. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Dovitinib Investigated for use/treatment in multiple myeloma and solid tumors. Dronabinol A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Elagolix A gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis. Elexacaftor A small molecule CFTR corrector used in combination with tezacaftor and ivacaftor for the treatment of cystic fibrosis patients with one F508del-CFTR mutation. Enasidenib An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. Eslicarbazepine An antiepileptic indicated as a monotherapy or adjunct therapy in the treatment of epilepsy. Eslicarbazepine acetate An anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy. Esomeprazole A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion. Ethambutol An antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB). Ethanol For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical... Ethinylestradiol An estradiol used as a contraceptive. Etoricoxib A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. Etravirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infections in combination with other antiretroviral agents. Evening primrose oil Evening primrose oil is used as part of over-the-counter dietary supplements. It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical... Felbamate An anticonvulsant used to treat severe epilepsy. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Fexinidazole An orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Fluconazole A triazole antifungal used to treat various fungal infections including candidiasis. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Garlic oil Not Annotated Gefitinib A tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Gestodene Gestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol... Ginsenoside C Not Available Goldenseal Not Annotated Idelalisib An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Ipriflavone Not Annotated Isavuconazole Indicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of... Isavuconazonium A triazole antifungal used for the treatment of invasive aspergillosis and mucormycosis. Isoniazid An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. Kava Not Available Ketoconazole A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. Lansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Laromustine Investigated for use/treatment in brain cancer, cancer/tumors (unspecified), colorectal cancer, leukemia (lymphoid), leukemia (myeloid), lung cancer, myelodysplastic syndrome, pediatric indications, and solid tumors. Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Letrozole An aromatase inhibitor used to treat breast cancer in postmenopausal women. Lobeglitazone Lobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use... Lonafarnib A potent farnesyl transferase inhibitor used to reduce mortality associated with Hutchinson-Gilford progeria syndrome (HGPS) and other progeroid laminopathies. Lonapegsomatropin A human growth hormone indicated in the treatment of growth failure due to inadequate endogenous growth hormone secretion. Lopinavir An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection. Loratadine A second generation antihistamine used to manage the symptoms of allergic rhinitis. Losartan An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. Luliconazole A topical antifungal agent used to treat fungal infections. Lynestrenol A progestin used for contraception and in the treatment of menstrual disorders. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Mavorixafor A CXC chemokine receptor 4 antagonist used to treat WHIM syndrome. Medical Cannabis The use of the plant species Cannabis sativa and Cannabis indica, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical... Memantine An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. Menadione The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Mephenytoin A phenylhydantoin used to treat refractory partial epilepsy. Methimazole A thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. Methsuximide A succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Midostaurin An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL). Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Modafinil A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. Naloxegol A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Nilutamide An antineoplastic hormone used to treat prostate cancer. Nilvadipine A calcium channel blocker used to manage arterial hypertension. Nivasorexant Nivasorexant is a small molecule drug. The usage of the INN stem '-orexant' in the name indicates that Nivasorexant is a orexin receptor antagonist. Nivasorexant has a monoisotopic molecular weight... Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Omeprazole A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. Oritavancin An antibacterial agent used to treat acute bacterial skin and skin structure infections caused by susceptible Gram-positive bacteria. Osilodrostat An oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism. Oxcarbazepine An anti-epileptic used in the treatment of partial-onset seizures. Pacritinib A kinase inhibitor used for the treatment of primary and secondary myelofibrosis in adult patients with significantly reduced platelet counts. Paltusotine A somatostatin receptor agonist used to treat acromegaly in adults whose surgery is not an option or has not been effective. Pantoprazole A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Piperaquine For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638. Pirfenidone An agent used for the treatment of idiopathic pulmonary fibrosis (IPF). Pirtobrutinib A kinase inhibitor used to treat relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy. It is also used in adults with relapsed or refractory CLL/SLL who have previously received a covalent BTK inhibitor. Probenecid A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia. Progesterone A hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia. Quercetin A natural flavonoid found in foods and natural supplement products. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Regorafenib A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma. Remibrutinib A Bruton's tyrosine kinase inhibitor used to treat chronic spontaneous urticaria in adults. Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Rifamycin An antibacterial used to treat traveler's diarrhea. Rilpivirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Rotigotine A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome. Rucaparib A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Secnidazole A nitroimidazole antibiotic used to treat bacterial vaginosis. Seproxetine Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an... Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Sitaxentan Investigated for use/treatment in pulmonary hypertension, connective tissue diseases, hypertension, and congestive heart failure. Somapacitan A human growth hormone analog subcutaneous injection indicated for adults with growth hormone deficiency. Somatotropin A recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adults. Sorafenib A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma. Stiripentol An antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome. Sulfanilamide A sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. Tecovirimat An antiviral medication used to treat smallpox, monkeypox, and cowpox. Telmisartan An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. Telotristat ethyl A tryptophan hydroxylase inhibitor that is used to treat carcinoid syndrome diarrhea. Tezacaftor A CFTR corrector used to treat cystic fibrosis in patients with susceptible mutations (e.g. F508del). Thalidomide A medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum. Ticlopidine A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA). Tilidine A synthetic opioid indicated in the treatment of severe pain. Tioconazole An imidazole antifungal used to treat vulvovaginal candidiasis. Tipranavir A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Topiramate An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. Topiroxostat Indicated for the treatment of gout and hyperurcemia in Japan. Tovorafenib A type II RAF inhibitor used to treat pediatric low-grade glioma with BRAF gene mutations. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Treosulfan A DNA alkylating agent used in the context of myeloablative conditioning prior to allogeneic hemoatopoietic stem cell transplantation. Triclabendazole An anthelmintic drug used to treat fascioliasis. Troglitazone For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise. Ubrogepant An oral CGRP antagonist used in the acute treatment of migraine with or without aura. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Vardenafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction. Vismodegib A hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. Vonoprazan A potassium-competitive acid blocker used in the treatment of acid-related disorders and as an adjunct to Helicobacter pylori eradication. Voriconazole A triazole compound used to treat fungal infections. Warfarin A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. Zafirlukast A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. Zonisamide A sulfonamide anticonvulsant used to treat partial seizures. Zucapsaicin A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. - Drugs & Drug Targets