Armodafinil is a stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD.
- Mechanism
- Curator reviewed
Nuvigil (armodafinil) is a single-isomer of modafini. The exact mechanism of action is unknown. Armodafinil belongs to a class of drugs known as eugeroics, which are stimulants that provide long-lasting mental arousal. Pharmacologically, armodafinil does not bind to or inhibit several receptors and enzymes potentially relevant for sleep/wake regulation. Armodafinil is not a direct- or indirect-acting dopamine receptor agonist. However, in vitro, both armodafinil and modafinil bind to the dopamine transporter and inhibit dopamine reuptake. [Medilexicon]
- Primary indication
- Investigated for use/treatment in sleep disorders, obstructive sleep apnea, schizophrenia and schizoaffective disorders, depression, and bipolar disorders.Curator reviewed · 3 structured indications
- Formula / weight
- C15H15NO2S · 273.35 g/mol (avg)
- First approval
- United States, 2007
- Also known as
- R-modafinil
- Code names
- CEP-10952 · CEP-10953 · CRL-40982
- Brand names
Resolves to
YFGHCGITMMYXAQ-LJQANCHMSA-NSMILESNC(=O)C[S@@](=O)C(C1=CC=CC=C1)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Armodafinil, and which of those have an active Phase 3 trial?
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