COMT Inhibitors

Name

COMT Inhibitors

Accession Number

DBCAT002655 (DBCAT000745, DBCAT003328, DBCAT003695)

Description

Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.

Drugs

Drug	Drug Description
3,5-Dinitrocatechol	Not Available
Opicapone	A catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor.
Tolcapone	A catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease.
Entacapone	A selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease.
Quercetin	A natural flavonoid found in foods and natural supplement products.
Testosterone propionate	A slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.

Drugs & Drug Targets

Drug	Target	Type
3,5-Dinitrocatechol	Catechol O-methyltransferase	target
Opicapone	Cytochrome P450 2C19	enzyme
Opicapone	Cytochrome P450 2C8	enzyme
Opicapone	Catechol O-methyltransferase	target
Opicapone	Solute carrier organic anion transporter family member 1B1	transporter
Opicapone	P-glycoprotein 1	transporter
Opicapone	ATP-binding cassette sub-family G member 2	transporter
Opicapone	Solute carrier organic anion transporter family member 1B3	transporter
Opicapone	Solute carrier organic anion transporter family member 2B1	transporter
Opicapone	Cytochrome P450 2C9	enzyme
Opicapone	Cytochrome P450 1A2	enzyme
Opicapone	Cytochrome P450 2B6	enzyme
Tolcapone	Catechol O-methyltransferase	target
Tolcapone	Cytochrome P450 2C9	enzyme
Entacapone	Catechol O-methyltransferase	target
Entacapone	Catechol O-methyltransferase	enzyme
Entacapone	UDP-glucuronosyltransferase 1-9	enzyme
Entacapone	Cytochrome P450 2D6	enzyme
Quercetin	Tyrosine-protein kinase HCK	target
Quercetin	Cytochrome P450 2C8	enzyme
Quercetin	Multidrug resistance-associated protein 1	transporter
Quercetin	Canalicular multispecific organic anion transporter 1	transporter
Quercetin	Monocarboxylate transporter 2	transporter
Quercetin	Solute carrier organic anion transporter family member 2B1	transporter
Quercetin	P-glycoprotein 1	transporter
Quercetin	Monocarboxylate transporter 1	transporter
Quercetin	ATP-binding cassette sub-family G member 2	transporter
Quercetin	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	target
Quercetin	UDP-glucuronosyltransferase 3A1	target
Quercetin	ATP synthase subunit alpha, mitochondrial	target
Quercetin	ATP synthase subunit beta, mitochondrial	target
Quercetin	ATP synthase subunit gamma, mitochondrial	target
Quercetin	Serine/threonine-protein kinase pim-1	target
Quercetin	HTH-type transcriptional regulator TtgR	target
Quercetin	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	target
Quercetin	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ	target
Quercetin	Serine/threonine-protein kinase 17B	target
Quercetin	Estrogen receptor alpha	target
Quercetin	Estrogen receptor beta	target
Quercetin	Ribosyldihydronicotinamide dehydrogenase [quinone]	target
Quercetin	Serum albumin	carrier
Quercetin	Aryl hydrocarbon receptor	target
Quercetin	Cytochrome P450 1B1	target
Quercetin	Actin, cytoplasmic 1	target
Quercetin	Casein kinase II subunit alpha	target
Quercetin	Casein kinase II subunit beta	target
Quercetin	Eukaryotic translation initiation factor 3 subunit F	target
Quercetin	Heat shock protein HSP 90-alpha	target
Quercetin	Heat shock-related 70 kDa protein 2	target
Quercetin	RuvB-like 2	target
Quercetin	Splicing factor 3B subunit 3	target
Quercetin	Ubiquitin-like modifier-activating enzyme 1	target
Quercetin	Sex hormone-binding globulin	target
Quercetin	Carbonyl reductase [NADPH] 1	target
Quercetin	CCAAT/enhancer-binding protein beta	target
Quercetin	Nuclear receptor subfamily 1 group I member 2	target
Quercetin	Solute carrier organic anion transporter family member 1B1	transporter
Quercetin	Cytochrome P450 2C9	enzyme
Quercetin	Cytochrome P450 1A2	enzyme
Quercetin	Cytochrome P450 2E1	enzyme
Quercetin	Cytochrome P450 2C19	enzyme
Quercetin	Cytochrome P450 3A Subfamily	enzyme
Quercetin	Cytochrome P450 2D6	enzyme
Testosterone propionate	Androgen receptor	target
Testosterone propionate	Catechol O-methyltransferase	enzyme
Testosterone propionate	UDP-glucuronosyltransferase 1-1	enzyme
Testosterone propionate	3-oxo-5-alpha-steroid 4-dehydrogenase	enzyme
Testosterone propionate	Cytochrome P450 3A4	enzyme
Testosterone propionate	P-glycoprotein 1	transporter
Testosterone propionate	Sex hormone-binding globulin	carrier
Testosterone propionate	Serum albumin	carrier