COMT Inhibitors

Name
COMT Inhibitors
Accession Number
DBCAT002655  (DBCAT000745, DBCAT003328, DBCAT003695)
Description

Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.

Drugs
DrugDrug Description
3,5-DinitrocatecholNot Available
OpicaponeA catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor.
TolcaponeA catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease.
EntacaponeA selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease.
QuercetinA natural flavonoid found in foods and natural supplement products.
Testosterone propionateA slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
Drugs & Drug Targets
DrugTargetType
3,5-DinitrocatecholCatechol O-methyltransferasetarget
OpicaponeCytochrome P450 2C19enzyme
OpicaponeCytochrome P450 2C8enzyme
OpicaponeCatechol O-methyltransferasetarget
OpicaponeSolute carrier organic anion transporter family member 1B1transporter
OpicaponeP-glycoprotein 1transporter
OpicaponeATP-binding cassette sub-family G member 2transporter
OpicaponeSolute carrier organic anion transporter family member 1B3transporter
OpicaponeSolute carrier organic anion transporter family member 2B1transporter
OpicaponeCytochrome P450 2C9enzyme
OpicaponeCytochrome P450 1A2enzyme
OpicaponeCytochrome P450 2B6enzyme
TolcaponeCatechol O-methyltransferasetarget
TolcaponeCytochrome P450 2C9enzyme
EntacaponeCatechol O-methyltransferasetarget
EntacaponeCatechol O-methyltransferaseenzyme
EntacaponeUDP-glucuronosyltransferase 1-9enzyme
EntacaponeCytochrome P450 2D6enzyme
QuercetinTyrosine-protein kinase HCKtarget
QuercetinCytochrome P450 2C8enzyme
QuercetinMultidrug resistance-associated protein 1transporter
QuercetinCanalicular multispecific organic anion transporter 1transporter
QuercetinMonocarboxylate transporter 2transporter
QuercetinSolute carrier organic anion transporter family member 2B1transporter
QuercetinP-glycoprotein 1transporter
QuercetinMonocarboxylate transporter 1transporter
QuercetinATP-binding cassette sub-family G member 2transporter
QuercetinPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
QuercetinUDP-glucuronosyltransferase 3A1target
QuercetinATP synthase subunit alpha, mitochondrialtarget
QuercetinATP synthase subunit beta, mitochondrialtarget
QuercetinATP synthase subunit gamma, mitochondrialtarget
QuercetinSerine/threonine-protein kinase pim-1target
QuercetinHTH-type transcriptional regulator TtgRtarget
Quercetin3-hydroxyisobutyryl-CoA hydrolase, mitochondrialtarget
Quercetin3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZtarget
QuercetinSerine/threonine-protein kinase 17Btarget
QuercetinEstrogen receptor alphatarget
QuercetinEstrogen receptor betatarget
QuercetinRibosyldihydronicotinamide dehydrogenase [quinone]target
QuercetinSerum albumincarrier
QuercetinAryl hydrocarbon receptortarget
QuercetinCytochrome P450 1B1target
QuercetinActin, cytoplasmic 1target
QuercetinCasein kinase II subunit alphatarget
QuercetinCasein kinase II subunit betatarget
QuercetinEukaryotic translation initiation factor 3 subunit Ftarget
QuercetinHeat shock protein HSP 90-alphatarget
QuercetinHeat shock-related 70 kDa protein 2target
QuercetinRuvB-like 2target
QuercetinSplicing factor 3B subunit 3target
QuercetinUbiquitin-like modifier-activating enzyme 1target
QuercetinSex hormone-binding globulintarget
QuercetinCarbonyl reductase [NADPH] 1target
QuercetinCCAAT/enhancer-binding protein betatarget
QuercetinNuclear receptor subfamily 1 group I member 2target
QuercetinSolute carrier organic anion transporter family member 1B1transporter
QuercetinCytochrome P450 2C9enzyme
QuercetinCytochrome P450 1A2enzyme
QuercetinCytochrome P450 2E1enzyme
QuercetinCytochrome P450 2C19enzyme
QuercetinCytochrome P450 3A Subfamilyenzyme
Testosterone propionateAndrogen receptortarget
Testosterone propionateCatechol O-methyltransferaseenzyme
Testosterone propionateUDP-glucuronosyltransferase 1-1enzyme
Testosterone propionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone propionateCytochrome P450 3A4enzyme
Testosterone propionateP-glycoprotein 1transporter
Testosterone propionateSex hormone-binding globulincarrier
Testosterone propionateSerum albumincarrier