Immunoglobulin Fc Fragments
- Name
- Immunoglobulin Fc Fragments
- Accession Number
- DBCAT002951
- Description
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
- Drugs
Drug Drug Description Etanercept A protein therapy based on the binding fragment of the tumour necrosis factor alpha receptor used to treat severe rheumatoid arthritis and moderate to severe plaque psoriasis. Efgartigimod alfa A neonatal Fc receptor blocker used to treat generalized myasthenia gravis in patients who are AChR-antibody positive. PRO-542 Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, HIV infection, and pediatric indications. - Drugs & Drug Targets