Tricyclics and Other Norepinephrine-reuptake Inhibitors

Accession Number

DBCAT003664

Description

Not Available

Drugs

Drug	Drug Description
Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
Imipramine	A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
Nortriptyline	A tricyclic antidepressant used in the treatment of depression.
Trimipramine	A tricyclic antidepressant used to treat depression.
Maprotiline	A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression.
Doxepin	A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
Desipramine	A tricyclic antidepressant used in the treatment of depression.
Clomipramine	A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder.

Drugs & Drug Targets

Drug	Target	Type
Amitriptyline	Sodium-dependent serotonin transporter	target
Amitriptyline	Sodium-dependent noradrenaline transporter	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 2	target
Amitriptyline	Alpha-2A adrenergic receptor	target
Amitriptyline	Cytochrome P450 1A2	enzyme
Amitriptyline	Cytochrome P450 2C19	enzyme
Amitriptyline	Cytochrome P450 2D6	enzyme
Amitriptyline	Serum albumin	carrier
Amitriptyline	Alpha-1-acid glycoprotein 1	carrier
Amitriptyline	Histamine H1 receptor	target
Amitriptyline	5-hydroxytryptamine receptor 2A	target
Amitriptyline	5-hydroxytryptamine receptor 1A	target
Amitriptyline	Alpha-1A adrenergic receptor	target
Amitriptyline	Cytochrome P450 3A4	enzyme
Amitriptyline	Cytochrome P450 3A5	enzyme
Amitriptyline	Potassium voltage-gated channel subfamily A member 1	target
Amitriptyline	Alpha-1D adrenergic receptor	target
Amitriptyline	Delta-type opioid receptor	target
Amitriptyline	Kappa-type opioid receptor	target
Amitriptyline	High affinity nerve growth factor receptor	target
Amitriptyline	BDNF/NT-3 growth factors receptor	target
Amitriptyline	Cytochrome P450 2C9	enzyme
Amitriptyline	Cytochrome P450 2B6	enzyme
Amitriptyline	Cytochrome P450 2C8	enzyme
Amitriptyline	Histamine H2 receptor	target
Amitriptyline	Histamine H4 receptor	target
Amitriptyline	Sigma non-opioid intracellular receptor 1	target
Amitriptyline	5-hydroxytryptamine receptor 2C	target
Amitriptyline	Alpha-1B adrenergic receptor	target
Amitriptyline	5-hydroxytryptamine receptor 7	target
Amitriptyline	5-hydroxytryptamine receptor 1D	target
Amitriptyline	Mu-type opioid receptor	target
Amitriptyline	5-hydroxytryptamine receptor 1B	target
Amitriptyline	5-hydroxytryptamine receptor 6	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 3	target
Amitriptyline	UDP-glucuronosyltransferase 2B10	enzyme
Amitriptyline	5-hydroxytryptamine receptor 1C	target
Amitriptyline	Muscarinic acetylcholine receptor	target
Amitriptyline	HERG human cardiac K+ channel	target
Amitriptyline	P-glycoprotein 1	transporter
Amitriptyline	UDP-glucuronosyltransferase 1-4	enzyme
Amitriptyline	Glutathione S-transferases (Cytosolic)	enzyme
Imipramine	Sodium-dependent noradrenaline transporter	target
Imipramine	Sodium-dependent serotonin transporter	target
Imipramine	Cytochrome P450 1A2	enzyme
Imipramine	Cytochrome P450 2C19	enzyme
Imipramine	Cytochrome P450 2D6	enzyme
Imipramine	Histamine H1 receptor	target
Imipramine	Alpha-1A adrenergic receptor	target
Imipramine	5-hydroxytryptamine receptor 2A	target
Imipramine	Muscarinic acetylcholine receptor M1	target
Imipramine	Muscarinic acetylcholine receptor M2	target
Imipramine	Muscarinic acetylcholine receptor M3	target
Imipramine	Muscarinic acetylcholine receptor M4	target
Imipramine	Muscarinic acetylcholine receptor M5	target
Imipramine	Potassium voltage-gated channel subfamily D member 2	target
Imipramine	Potassium voltage-gated channel subfamily D member 3	target
Imipramine	Alpha-1D adrenergic receptor	target
Imipramine	Alpha-1-acid glycoprotein 1	carrier
Imipramine	Solute carrier family 22 member 2	transporter
Imipramine	Solute carrier family 22 member 3	transporter
Imipramine	P-glycoprotein 1	transporter
Imipramine	Solute carrier family 22 member 4	transporter
Imipramine	Cytochrome P450 3A4	enzyme
Imipramine	Cytochrome P450 2B6	enzyme
Imipramine	Cytochrome P450 2C18	enzyme
Imipramine	Cytochrome P450 2E1	enzyme
Imipramine	Cytochrome P450 3A7	enzyme
Imipramine	5-hydroxytryptamine receptor 2C	target
Imipramine	Alpha-1B adrenergic receptor	target
Imipramine	5-hydroxytryptamine receptor 7	target
Imipramine	D(1) dopamine receptor	target
Imipramine	Dopamine D2 receptor	target
Imipramine	Potassium voltage-gated channel subfamily H member 2	target
Imipramine	Sodium-dependent dopamine transporter	target
Imipramine	5-hydroxytryptamine receptor 1A	target
Imipramine	5-hydroxytryptamine receptor 6	target
Imipramine	Potassium voltage-gated channel subfamily H member 1	target
Imipramine	Serum albumin	carrier
Imipramine	Alpha-1-acid glycoprotein 2	target
Nortriptyline	Sodium-dependent serotonin transporter	target
Nortriptyline	Sodium-dependent noradrenaline transporter	target
Nortriptyline	Cytochrome P450 1A2	enzyme
Nortriptyline	Cytochrome P450 2D6	enzyme
Nortriptyline	Serum albumin	carrier
Nortriptyline	Alpha-1-acid glycoprotein 1	carrier
Nortriptyline	Histamine H1 receptor	target
Nortriptyline	5-hydroxytryptamine receptor 2A	target
Nortriptyline	Alpha-1A adrenergic receptor	target
Nortriptyline	5-hydroxytryptamine receptor 1A	target
Nortriptyline	Cytochrome P450 3A4	enzyme
Nortriptyline	Cytochrome P450 3A5	enzyme
Nortriptyline	Alpha-1D adrenergic receptor	target
Nortriptyline	Cytochrome P450 2C19	enzyme
Nortriptyline	Cytochrome P450 2E1	enzyme
Nortriptyline	5-hydroxytryptamine receptor 2C	target
Nortriptyline	Alpha-1B adrenergic receptor	target
Nortriptyline	Alpha-2 adrenergic receptors	target
Nortriptyline	Beta adrenergic receptor	target
Nortriptyline	Dopamine D2 receptor	target
Nortriptyline	Sigma receptor	target
Nortriptyline	5-hydroxytryptamine receptor 1C	target
Nortriptyline	Sodium-dependent noradrenaline transporter	transporter
Nortriptyline	Muscarinic acetylcholine receptor	target
Nortriptyline	P-glycoprotein 1	transporter
Trimipramine	Sodium-dependent serotonin transporter	target
Trimipramine	Sodium-dependent noradrenaline transporter	target
Trimipramine	Cytochrome P450 2D6	enzyme
Trimipramine	Sodium-dependent dopamine transporter	target
Trimipramine	5-hydroxytryptamine receptor 2A	target
Trimipramine	5-hydroxytryptamine receptor 1A	target
Trimipramine	Alpha-1A adrenergic receptor	target
Trimipramine	Alpha-1B adrenergic receptor	target
Trimipramine	Dopamine D2 receptor	target
Trimipramine	Alpha-2B adrenergic receptor	target
Trimipramine	Histamine H1 receptor	target
Trimipramine	Cytochrome P450 2C19	enzyme
Trimipramine	P-glycoprotein 1	transporter
Trimipramine	Cytochrome P450 2C9	enzyme
Trimipramine	5-hydroxytryptamine receptor 2C	target
Trimipramine	5-hydroxytryptamine receptor 3A	target
Trimipramine	5-hydroxytryptamine receptor 1D	target
Trimipramine	Alpha-2A adrenergic receptor	target
Trimipramine	D(1) dopamine receptor	target
Trimipramine	Beta adrenergic receptor	target
Trimipramine	Muscarinic acetylcholine receptor	target
Trimipramine	5-hydroxytryptamine receptor 1C	target
Maprotiline	Histamine H1 receptor	target
Maprotiline	Sodium-dependent noradrenaline transporter	target
Maprotiline	Alpha-1 adrenergic receptors	target
Maprotiline	Cytochrome P450 2D6	enzyme
Maprotiline	Alpha-1-acid glycoprotein 1	carrier
Maprotiline	Muscarinic acetylcholine receptor M1	target
Maprotiline	Muscarinic acetylcholine receptor M2	target
Maprotiline	Muscarinic acetylcholine receptor M3	target
Maprotiline	Muscarinic acetylcholine receptor M4	target
Maprotiline	Muscarinic acetylcholine receptor M5	target
Maprotiline	Cytochrome P450 1A2	enzyme
Maprotiline	5-hydroxytryptamine receptor 2A	target
Maprotiline	5-hydroxytryptamine receptor 2C	target
Maprotiline	5-hydroxytryptamine receptor 7	target
Maprotiline	Dopamine D2 receptor	target
Maprotiline	Alpha-2 adrenergic receptors	target
Doxepin	Sodium-dependent serotonin transporter	target
Doxepin	Sodium-dependent noradrenaline transporter	target
Doxepin	Histamine H1 receptor	target
Doxepin	Histamine H2 receptor	target
Doxepin	Cytochrome P450 2D6	enzyme
Doxepin	Muscarinic acetylcholine receptor M1	target
Doxepin	Muscarinic acetylcholine receptor M2	target
Doxepin	Muscarinic acetylcholine receptor M3	target
Doxepin	Muscarinic acetylcholine receptor M4	target
Doxepin	Muscarinic acetylcholine receptor M5	target
Doxepin	Alpha-1A adrenergic receptor	target
Doxepin	5-hydroxytryptamine receptor 1A	target
Doxepin	5-hydroxytryptamine receptor 2A	target
Doxepin	Cytochrome P450 2C19	enzyme
Doxepin	Cytochrome P450 2C9	enzyme
Doxepin	Cytochrome P450 1A2	enzyme
Doxepin	P-glycoprotein 1	transporter
Doxepin	5-hydroxytryptamine receptor 2B	target
Doxepin	5-hydroxytryptamine receptor 2C	target
Doxepin	Alpha-1B adrenergic receptor	target
Doxepin	Alpha-1D adrenergic receptor	target
Doxepin	Cytochrome P450 3A4	enzyme
Doxepin	5-hydroxytryptamine receptor 6	target
Doxepin	Histamine H4 receptor	target
Doxepin	Potassium voltage-gated channel subfamily H member 2	target
Doxepin	Serum albumin	carrier
Doxepin	Alpha-1-acid glycoprotein 1	carrier
Desipramine	Muscarinic acetylcholine receptor M1	target
Desipramine	Sodium-dependent noradrenaline transporter	target
Desipramine	Beta-2 adrenergic receptor	target
Desipramine	Muscarinic acetylcholine receptor M2	target
Desipramine	Sodium-dependent serotonin transporter	target
Desipramine	Histamine H1 receptor	target
Desipramine	Beta-1 adrenergic receptor	target
Desipramine	Cytochrome P450 2D6	enzyme
Desipramine	Muscarinic acetylcholine receptor M3	target
Desipramine	Muscarinic acetylcholine receptor M4	target
Desipramine	Muscarinic acetylcholine receptor M5	target
Desipramine	Alpha-1 adrenergic receptors	target
Desipramine	5-hydroxytryptamine receptor 2A	target
Desipramine	Alpha-1-acid glycoprotein 1	carrier
Desipramine	Cytochrome P450 2B6	enzyme
Desipramine	Cytochrome P450 3A4	enzyme
Desipramine	Solute carrier family 22 member 2	transporter
Desipramine	Solute carrier family 22 member 1	transporter
Desipramine	Solute carrier family 22 member 3	transporter
Desipramine	Solute carrier family 22 member 5	transporter
Desipramine	P-glycoprotein 1	transporter
Desipramine	Solute carrier family 22 member 4	transporter
Desipramine	Cytochrome P450 1A2	enzyme
Desipramine	Cytochrome P450 2E1	enzyme
Desipramine	Sphingomyelin phosphodiesterase	target
Desipramine	5-hydroxytryptamine receptor 1A	target
Desipramine	5-hydroxytryptamine receptor 2C	target
Desipramine	Dopamine D2 receptor	target
Desipramine	Alpha-2 adrenergic receptors	target
Clomipramine	Sodium-dependent serotonin transporter	target
Clomipramine	Sodium-dependent noradrenaline transporter	target
Clomipramine	Glutathione S-transferase P	target
Clomipramine	5-hydroxytryptamine receptor 2A	target
Clomipramine	Cytochrome P450 1A2	enzyme
Clomipramine	Cytochrome P450 2D6	enzyme
Clomipramine	Cytochrome P450 2C19	enzyme
Clomipramine	P-glycoprotein 1	transporter
Clomipramine	Cytochrome P450 3A4	enzyme
Clomipramine	5-hydroxytryptamine receptor 2B	target
Clomipramine	5-hydroxytryptamine receptor 2C	target
Clomipramine	Serum albumin	carrier