Heavy Metal Antagonists

Name
Heavy Metal Antagonists
Accession Number
DBCAT003716
Description

Not Available

Drugs
DrugDrug Description
DeferoxamineA chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias.
PenicillamineA chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis.
Edetic acidA chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias.
DeferasiroxAn iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin.
DimercaprolA chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.
DeferiproneAn iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes.
TriethylenetetramineA copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate.
Drugs & Drug Targets
DrugTargetType
DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DeferoxamineIrontarget
DeferoxamineAluminumtarget
DeferoxamineAmyloid beta A4 proteintarget
PenicillamineSolute carrier organic anion transporter family member 1B1transporter
PenicillamineCoppertarget
Edetic acidLeadtarget
Edetic acidIrontarget
Edetic acidManganese cationtarget
Edetic acidAdenosine deaminaseenzyme
Edetic acidSerum paraoxonase/lactonase 3enzyme
Edetic acidCytochrome P450 19A1enzyme
DeferasiroxIrontarget
DeferasiroxCytochrome P450 3A4enzyme
DeferasiroxUDP-glucuronosyltransferase 1-1enzyme
DeferasiroxUDP-glucuronosyltransferase 1-3enzyme
DeferasiroxUDP-glucuronosyltransferase 1-9enzyme
DeferasiroxCytochrome P450 2C8enzyme
DeferasiroxCytochrome P450 1A2enzyme
DimercaprolArsenictarget
DimercaprolCadmiumtarget
DimercaprolMercurytarget
DimercaprolAmyloid beta A4 proteintarget
DeferiproneUDP-glucuronosyltransferase 1-6enzyme
DeferiproneIrontarget
TriethylenetetramineGlypican-1transporter