Antivirals used in combination for the treatment of HIV infections

Name
Antivirals used in combination for the treatment of HIV infections
Accession Number
DBCAT005506
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
LamivudineA reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.
AbacavirAn antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV.
Tenofovir disoproxilA nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection.
EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
NevirapineA non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection.
EfavirenzA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
StavudineA dideoxynucleoside used in the treatment of HIV infection.
RilpivirineA non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1).
ElvitegravirAn antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
CobicistatA CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection.
LopinavirAn HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
DolutegravirAn antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents.
DarunavirA HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies.
AtazanavirAn antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV.
RaltegravirAn antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals.
Tenofovir alafenamideA nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.
BictegravirAn integrase inhibitor used to treat HIV infections.
DoravirineA non-nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals to treat HIV-1 infections.
Drugs & Drug Targets
DrugTargetType
ZidovudineAlbumincarrier
ZidovudineCytochrome P450 2A6enzyme
ZidovudineCytochrome P450 2C9enzyme
ZidovudineCytochrome P450 3A4enzyme
ZidovudineReverse transcriptase/RNaseHtarget
ZidovudineSolute carrier family 22 member 2transporter
ZidovudineSolute carrier family 22 member 6transporter
ZidovudineSolute carrier family 22 member 7transporter
ZidovudineOrganic anion transporter 3transporter
ZidovudineSolute carrier family 22 member 11transporter
ZidovudineSodium/nucleoside cotransporter 1transporter
ZidovudineEquilibrative nucleoside transporter 2transporter
ZidovudineATP-dependent translocase ABCB1transporter
ZidovudineATP-binding cassette sub-family C member 4transporter
ZidovudineATP-binding cassette sub-family C member 5transporter
ZidovudineBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
ZidovudineTelomerase reverse transcriptasetarget
ZidovudineThymidine kinase, cytosolicenzyme
ZidovudineUDP-glucuronosyltransferase 2B7enzyme
ZidovudineUDP-glucuronosyltransferase 1A1enzyme
ZidovudineGag-Pol polyproteintarget
ZidovudineReceptor-type tyrosine-protein kinase FLT3target
LamivudineDNAtarget
LamivudineProtein Ptarget
LamivudineMultidrug resistance-associated protein 1transporter
LamivudineSolute carrier family 22 member 6transporter
LamivudineBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
LamivudineReverse transcriptase/RNaseHtarget
LamivudineSolute carrier family 22 member 1transporter
LamivudineSolute carrier family 22 member 2transporter
LamivudineSolute carrier family 22 member 3transporter
LamivudineDeoxycytidine kinaseenzyme
LamivudineUMP-CMP kinaseenzyme
LamivudinePhosphoglycerate kinase 1enzyme
LamivudineNucleoside diphosphate kinase Aenzyme
LamivudineNucleoside diphosphate kinase Benzyme
LamivudineCholine-phosphate cytidylyltransferase Aenzyme
LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
LamivudineATP-dependent translocase ABCB1transporter
LamivudineATP-binding cassette sub-family C member 4transporter
LamivudineATP-binding cassette sub-family C member 3transporter
LamivudineATP-binding cassette sub-family C member 2transporter
Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
LamivudineAlbumincarrier
LamivudineGag-Pol polyproteintarget
AbacavirAlcohol dehydrogenase 6enzyme
AbacavirUDP-glucuronosyltransferase 1A1enzyme
AbacavirReverse transcriptase/RNaseHtarget
AbacavirAdenosine kinaseenzyme
AbacavirGag-Pol polyproteintarget
Tenofovir disoproxilReverse transcriptase/RNaseHtarget
Tenofovir disoproxilSolute carrier family 22 member 6transporter
Tenofovir disoproxilOrganic anion transporter 3transporter
Tenofovir disoproxilATP-binding cassette sub-family C member 10transporter
Tenofovir disoproxilATP-binding cassette sub-family C member 4transporter
Tenofovir disoproxilATP-binding cassette sub-family C member 2transporter
Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
Tenofovir disoproxilATP-dependent translocase ABCB1transporter
Tenofovir disoproxilNucleoside diphosphokinaseenzyme
Tenofovir disoproxilCreatine Kinasesenzyme
Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
Tenofovir disoproxilGag-Pol polyproteintarget
EmtricitabineReverse transcriptase/RNaseHtarget
EmtricitabineDeoxycytidine kinaseenzyme
EmtricitabineAlbumincarrier
EmtricitabineMultidrug and toxin extrusion protein 1transporter
EmtricitabineGag-Pol polyproteintarget
NevirapineCytochrome P450 3A4enzyme
NevirapineCytochrome P450 2B6enzyme
NevirapineCytochrome P450 3A5enzyme
NevirapineCytochrome P450 2C9enzyme
NevirapineCytochrome P450 2A6enzyme
NevirapineCytochrome P450 2D6enzyme
NevirapineReverse transcriptase/RNaseHtarget
NevirapineAlbumincarrier
NevirapineCytochrome P450 1A2enzyme
NevirapineSolute carrier family 22 member 1transporter
NevirapineCytochrome P450 3A7enzyme
NevirapineGag-Pol polyproteintarget
EfavirenzCytochrome P450 2B6enzyme
EfavirenzCytochrome P450 3A4enzyme
EfavirenzCytochrome P450 2C19enzyme
EfavirenzCytochrome P450 2C9enzyme
EfavirenzCytochrome P450 1A2enzyme
EfavirenzCytochrome P450 2D6enzyme
EfavirenzReverse transcriptase/RNaseHtarget
EfavirenzCytochrome P450 2C8enzyme
EfavirenzAlbumincarrier
EfavirenzCytochrome P450 3A5enzyme
EfavirenzCytochrome P450 3A7enzyme
EfavirenzUDP-glucuronosyltransferase 1A1enzyme
EfavirenzBile salt export pumptransporter
EfavirenzSolute carrier family 22 member 1transporter
EfavirenzGag-Pol polyproteintarget
StavudineSolute carrier family 22 member 6transporter
StavudineReverse transcriptase/RNaseHtarget
StavudineSodium/nucleoside cotransporter 1transporter
StavudineAlbumincarrier
StavudineGag-Pol polyproteintarget
RilpivirineCytochrome P450 3A4enzyme
RilpivirineReverse transcriptase/RNaseHtarget
RilpivirineNuclear receptor subfamily 1 group I member 2target
RilpivirineCytochrome P450 2C19enzyme
RilpivirineCytochrome P450 2B6enzyme
RilpivirineATP-dependent translocase ABCB1transporter
RilpivirineBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
RilpivirineSolute carrier organic anion transporter family member 1B1transporter
RilpivirineSolute carrier organic anion transporter family member 1B3transporter
RilpivirineAlbumincarrier
RilpivirineCytochrome P450 2D6enzyme
RilpivirineCytochrome P450 2C9enzyme
RilpivirineCytochrome P450 2C8enzyme
RilpivirineCytochrome P450 2E1enzyme
RilpivirineGag-Pol polyproteintarget
RilpivirineSodium channel protein type 10 subunit alphatarget
ElvitegravirIntegrasetarget
ElvitegravirCytochrome P450 3A4enzyme
ElvitegravirUDP-glucuronosyltransferase 1A1enzyme
ElvitegravirGag-Pol polyproteintarget
CobicistatCytochrome P450 2D6enzyme
CobicistatATP-dependent translocase ABCB1transporter
CobicistatBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
CobicistatCytochrome P450 3A5enzyme
CobicistatCytochrome P450 3A7enzyme
CobicistatSolute carrier organic anion transporter family member 1B1transporter
CobicistatSolute carrier organic anion transporter family member 1B3transporter
CobicistatCytochrome P450 3A4target
CobicistatCytochrome P450 3A4enzyme
CobicistatCytochrome P450 3A5target
CobicistatCytochrome P450 3A7target
LopinavirHuman immunodeficiency virus type 1 proteasetarget
LopinavirCytochrome P450 3A4enzyme
LopinavirCytochrome P450 2D6enzyme
LopinavirCytochrome P450 2C19enzyme
LopinavirATP-dependent translocase ABCB1transporter
LopinavirCytochrome P450 2B6enzyme
LopinavirCytochrome P450 2C9enzyme
LopinavirCytochrome P450 3A Subfamilyenzyme
LopinavirSolute carrier organic anion transporter family member 1B1transporter
LopinavirSolute carrier organic anion transporter family member 1B3transporter
LopinavirBile salt export pumptransporter
LopinavirCytochrome P450 1A2enzyme
LopinavirAlpha-1-acid glycoprotein 1carrier
LopinavirAlbumincarrier
RitonavirHuman immunodeficiency virus type 1 proteasetarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirATP-dependent translocase ABCB1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirATP-binding cassette sub-family C member 2transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirAlbumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter
RitonavirGag-Pol polyproteintarget
DolutegravirUDP-glucuronosyltransferase 1A1enzyme
DolutegravirCytochrome P450 3A Subfamilyenzyme
DolutegravirIntegrasetarget
DolutegravirSolute carrier family 22 member 2transporter
DolutegravirUDP-glucuronosyltransferase 1A3enzyme
DolutegravirUDP-glucuronosyltransferase 1A9enzyme
DolutegravirBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DolutegravirSolute carrier family 22 member 6transporter
DolutegravirOrganic anion transporter 3transporter
DolutegravirATP-dependent translocase ABCB1transporter
DolutegravirMultidrug and toxin extrusion protein 1transporter
DolutegravirAlbumincarrier
Dolutegraviralpha1-acid glycoproteincarrier
DolutegravirGag-Pol polyproteintarget
DarunavirHuman immunodeficiency virus type 1 proteasetarget
DarunavirCytochrome P450 3A4enzyme
DarunavirSolute carrier organic anion transporter family member 1B1transporter
DarunavirATP-dependent translocase ABCB1transporter
DarunavirAlbumincarrier
DarunavirAlpha-1-acid glycoprotein 1carrier
DarunavirCytochrome P450 2D6enzyme
DarunavirGag-Pol polyproteintarget
AtazanavirHuman immunodeficiency virus type 1 proteasetarget
AtazanavirCytochrome P450 3A4enzyme
AtazanavirCytochrome P450 2C9enzyme
AtazanavirATP-dependent translocase ABCB1transporter
AtazanavirMultidrug resistance-associated protein 1transporter
AtazanavirAlbumincarrier
AtazanavirUDP-glucuronosyltransferase 1A1enzyme
AtazanavirSolute carrier organic anion transporter family member 1B1transporter
AtazanavirSolute carrier organic anion transporter family member 1B3transporter
AtazanavirCytochrome P450 2C8enzyme
AtazanavirBile salt export pumptransporter
Atazanaviralpha1-acid glycoproteincarrier
AtazanavirCytochrome P450 1A2enzyme
AtazanavirSolute carrier organic anion transporter family member 2B1transporter
AtazanavirCytochrome P450 3A5enzyme
AtazanavirCytochrome P450 3A7enzyme
AtazanavirGag-Pol polyproteintarget
RaltegravirUDP-glucuronosyltransferase 1A1enzyme
RaltegravirIntegrasetarget
RaltegravirGag-Pol polyproteintarget
Tenofovir alafenamideReverse transcriptase/RNaseHtarget
Tenofovir alafenamideATP-dependent translocase ABCB1transporter
Tenofovir alafenamideATP-binding cassette sub-family C member 4transporter
Tenofovir alafenamideSolute carrier family 22 member 6transporter
Tenofovir alafenamideOrganic anion transporter 3transporter
Tenofovir alafenamideLysosomal protective proteinenzyme
Tenofovir alafenamideLiver carboxylesterase 1enzyme
Tenofovir alafenamideBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
Tenofovir alafenamideSolute carrier organic anion transporter family member 1B1transporter
Tenofovir alafenamideSolute carrier organic anion transporter family member 1B3transporter
Tenofovir alafenamideReverse transcriptasetarget
Tenofovir alafenamideDNA polymerasetarget
Tenofovir alafenamideAlbumincarrier
Tenofovir alafenamideCytochrome P450 3A4enzyme
Tenofovir alafenamideAdenylate kinase isoenzyme 1enzyme
Tenofovir alafenamideAdenylate kinase 2, mitochondrialenzyme
Tenofovir alafenamideNucleoside diphosphate kinase Aenzyme
Tenofovir alafenamideNucleoside diphosphate kinase Benzyme
Tenofovir alafenamideGag-Pol polyproteintarget
BictegravirReverse transcriptase/RNaseHtarget
BictegravirIntegrasetarget
BictegravirCytochrome P450 3A4enzyme
BictegravirUDP-glucuronosyltransferase 1A1enzyme
BictegravirPOU domain, class 2, transcription factor 2enzyme
BictegravirMultidrug and toxin extrusion protein 1enzyme
DoravirineCytochrome P450 3A4enzyme
DoravirineCytochrome P450 3A5enzyme
DoravirineReverse transcriptase/RNaseHtarget
DoravirineGag-Pol polyproteintarget