Sphingosine 1 Phosphate Receptor Modulators

Name
Sphingosine 1 Phosphate Receptor Modulators
Accession Number
DBCAT005548
Description

Agents that affect the function of G-protein coupled SPHINGOSINE 1-PHOSPHATE RECEPTORS. Their binding to the receptors blocks lymphocyte migration and are often used as IMMUNOSUPPRESSANTS.

Drugs
DrugDrug Description
PonesimodA sphingosine 1-phosphate receptor modulator indicated to treat relapsing multiple sclerosis.
SiponimodA medication used to treat relapsing multiple sclerosis.
OzanimodA sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
CeralifimodCeralifimod is under investigation in clinical trial NCT01226745 (Phase 2 Extension Trial in Patients With Relapsing-remitting Multiple Sclerosis (RRMS)).
FingolimodA sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19.
Drugs & Drug Targets
DrugTargetType
PonesimodSphingosine 1-phosphate receptor 1target
PonesimodCytochrome P450 2J2enzyme
PonesimodCytochrome P450 3A4enzyme
PonesimodCytochrome P450 3A5enzyme
PonesimodCytochrome P450 4F3enzyme
PonesimodCytochrome P450 4F12enzyme
PonesimodUDP-glucuronosyltransferase 1-1enzyme
PonesimodUDP-glucuronosyltransferase 2B7enzyme
SiponimodSphingosine 1-phosphate receptor 5target
SiponimodSphingosine 1-phosphate receptor 1target
SiponimodCytochrome P450 3A4enzyme
SiponimodCytochrome P450 2C9enzyme
OzanimodSphingosine 1-phosphate receptor 1target
OzanimodSphingosine 1-phosphate receptor 5target
OzanimodAmine oxidase [flavin-containing] Btransporter
OzanimodATP-binding cassette sub-family G member 2transporter
OzanimodP-glycoprotein 1transporter
OzanimodFatty aldehyde dehydrogenaseenzyme
OzanimodAlcohol dehydrogenase class-3enzyme
OzanimodArylamine N-acetyltransferase 2enzyme
OzanimodCytochrome P450 2C8enzyme
OzanimodAmine oxidase [flavin-containing] Benzyme
OzanimodAldo-keto reductase family 1 member C1enzyme
OzanimodAldo-keto reductase family 1 member C2enzyme
OzanimodCytochrome P450 3A4enzyme
FingolimodSphingosine 1-phosphate receptor 5target
FingolimodSphingosine kinase 1enzyme
FingolimodCytochrome P450 2E1enzyme
FingolimodLeukotriene-B(4) omega-hydroxylase 1enzyme
FingolimodHistone deacetylase 1target
FingolimodExcitatory amino acid transporter 2transporter
FingolimodExcitatory amino acid transporter 1transporter
FingolimodP-glycoprotein 1transporter
FingolimodMultidrug resistance-associated protein 1transporter
FingolimodSphingosine 1-phosphate receptor 1target
FingolimodSphingosine 1-phosphate receptor 4target
FingolimodSphingosine 1-phosphate receptor 3target