NTCP Inhibitors

Name
NTCP Inhibitors
Accession Number
DBCAT005809
Description

Group of drugs that inhibit the sodium-taurocholate co-transporting polypeptide (NTCP).

Drugs
DrugDrug Description
RosiglitazoneA thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes.
ZafirlukastA leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma.
TiratricolA metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
SulfasalazineA salicylate used to treat Crohn's disease, ulcerative colitis, and rheumatoid arthritis.
CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
SulfobromophthaleinSulfobromophthalein or otherwise called bromsulphthalein is used as a test of liver function in humans .
Estrone sulfateAn estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.
Drugs & Drug Targets
DrugTargetType
RosiglitazonePeroxisome proliferator-activated receptor gammatarget
RosiglitazoneCytochrome P450 2C8enzyme
RosiglitazoneCytochrome P450 2C9enzyme
RosiglitazoneLong-chain-fatty-acid--CoA ligase 4target
RosiglitazoneSolute carrier organic anion transporter family member 1B1transporter
RosiglitazoneProstaglandin G/H synthase 1enzyme
RosiglitazoneCytochrome P450 1A2enzyme
RosiglitazoneCytochrome P450 2D6enzyme
RosiglitazoneSerum albumincarrier
RosiglitazonePeroxisome proliferator-activated receptor alphatarget
RosiglitazonePeroxisome proliferator-activated receptor deltatarget
RosiglitazoneRetinoic acid receptor RXR-alphatarget
RosiglitazoneRetinoic acid receptor RXR-betatarget
RosiglitazoneRetinoic acid receptor RXR-gammatarget
RosiglitazoneCytochrome P450 3A4enzyme
RosiglitazoneBile salt export pumptransporter
RosiglitazoneCytochrome P450 2B6enzyme
RosiglitazoneCytochrome P450 2E1enzyme
RosiglitazoneSodium/bile acid cotransportertransporter
ZafirlukastCysteinyl leukotriene receptor 1target
ZafirlukastCytochrome P450 2C9enzyme
ZafirlukastCytochrome P450 2C8enzyme
ZafirlukastProstaglandin G/H synthase 1enzyme
ZafirlukastCytochrome P450 3A4enzyme
ZafirlukastCytochrome P450 1A2enzyme
ZafirlukastCytochrome P450 2C19enzyme
ZafirlukastATP-binding cassette sub-family G member 2transporter
ZafirlukastCytochrome P450 2D6enzyme
ZafirlukastSodium/bile acid cotransportertransporter
TiratricolThyroid hormone receptor betatarget
TiratricolSodium/bile acid cotransportertransporter
SulfasalazineAcetyl-CoA acetyltransferase, mitochondrialtarget
SulfasalazineATP-binding cassette sub-family G member 2transporter
SulfasalazineCanalicular multispecific organic anion transporter 1transporter
SulfasalazineProstaglandin G/H synthase 2target
SulfasalazineProstaglandin G/H synthase 1target
SulfasalazineArachidonate 5-lipoxygenasetarget
SulfasalazineProton-coupled folate transportertransporter
SulfasalazinePhospholipase A2target
SulfasalazineSolute carrier organic anion transporter family member 1B1transporter
SulfasalazineSolute carrier organic anion transporter family member 1B3transporter
SulfasalazineSolute carrier organic anion transporter family member 2B1transporter
SulfasalazineSerum albumincarrier
SulfasalazineCystine/glutamate transportertarget
SulfasalazineNuclear factor NF-kappa-B p105 subunittarget
SulfasalazineNuclear factor NF-kappa-B p100 subunittarget
SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
SulfasalazinePeroxisome proliferator-activated receptor gammatarget
SulfasalazineSodium/bile acid cotransportertransporter
CyclosporineCalcium signal-modulating cyclophilin ligandtarget
CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
CyclosporineCalcineurin subunit B type 2target
CyclosporineCytochrome P450 3A5enzyme
CyclosporineCytochrome P450 3A4enzyme
CyclosporineP-glycoprotein 1transporter
CyclosporineBile salt export pumptransporter
CyclosporineIleal sodium/bile acid cotransportertransporter
CyclosporineSodium/bile acid cotransportertransporter
CyclosporineSolute carrier family 22 member 6transporter
CyclosporineMultidrug resistance-associated protein 7transporter
CyclosporineCanalicular multispecific organic anion transporter 1transporter
CyclosporineATP-binding cassette sub-family G member 2transporter
CyclosporineSolute carrier organic anion transporter family member 1B1transporter
CyclosporineCytochrome P450 2C19enzyme
CyclosporineCytochrome P450 2D6enzyme
CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
CyclosporineSolute carrier organic anion transporter family member 1B3transporter
SulfobromophthaleinSodium/bile acid cotransportertransporter
Estrone sulfateCytochrome P450 1A2enzyme
Estrone sulfateCytochrome P450 3A4enzyme
Estrone sulfateEstrogen receptor alphatarget
Estrone sulfateEstrogen receptor betatarget
Estrone sulfateSex hormone-binding globulincarrier
Estrone sulfateSerum albumincarrier
Estrone sulfateCytochrome P450 2C9enzyme
Estrone sulfateMultidrug and toxin extrusion protein 1transporter
Estrone sulfateMultidrug and toxin extrusion protein 2transporter
Estrone sulfateSodium/bile acid cotransportertransporter