Estrone sulfate is an estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment...
- Mechanism
- Curator reviewed
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
- Primary indication
- Estropipate is used for the treatment of moderate to severe vasomotor symptoms associated with the monopause, and moderate to severe symptoms of vulval and vaginal atrophy associated with the menopause.Curator reviewed · 9 structured indications
- Formula / weight
- C18H22O5S · 350.429 g/mol (avg)
- First approval
- Canada, 2003 · United States, 1977
- Also known as
- Estrone 3-sulfate · Estrone bisulfate · Estrone hemisulfate · Estrone hydrogen sulfate · Estrone sulphate
- Code names
- US-2917522
Resolves to
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Which drugs share a target with Estrone sulfate, and which of those have an active Phase 3 trial?
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