Yaws (DBCOND0000236)

Identifiers

Synonyms

Yaws, unspecified / Yaws (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Demeclocycline	A tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.	30S ribosomal proteintarget Vasopressin V2 receptortarget
Procaine benzylpenicillin	A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection.	No drug targets
Tetracycline	An antibiotic used to treat a wide variety of susceptible infections.	16S ribosomal RNAtarget Major prion proteintarget Albumincarrier Cytochrome P450 3A4enzyme Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter 30S ribosomal protein S3target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 30S ribosomal protein S7target Multidrug translocase MdfAtarget Protein-arginine deiminase type-4target Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01841203	Dual Point-of-care Test for the Diagnosis of Yaws	No drug interventions	Not Available	Not Available	completed
NCT03683745	Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia	No drug interventions	Not Available	Not Available	completed
NCT04453124	An Accessible Low-cost Plant Treatment for Cutaneous Ulcers	No drug interventions	treatment	2	completed
NCT03664063	PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )	Albendazole Azithromycin Diethylcarbamazine Ivermectin	treatment	2	completed
NCT02344628	Comparison of Two Different Doses of Azithromycin for Treatment of Yaws	Azithromycin	treatment	3	completed
NCT04753788	Evaluation of a LAMP Assay for T. Pallidum. Pertenue	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT01955252	Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea	Azithromycin	treatment	3	completed
NCT02775617	Azithromycin - Ivermectin Mass Drug Administration for Skin Disease	Azithromycin Ivermectin Permethrin	treatment	4	completed
NCT05764876	Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws)	Azithromycin Linezolid	treatment	3	active_not_recruiting
NCT03676140	Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )	Albendazole Azithromycin Diethylcarbamazine Ivermectin	treatment	3	completed
NCT01382004	Single-dose Azithromycin for the Treatment of Yaws	Azithromycin Benzylpenicillin	treatment	3	completed
NCT03490123	Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication	Azithromycin	treatment	4	completed