Procaine benzylpenicillin is a local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection. Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic.
- Mechanism
- Curator reviewed · 1 reference
Procaine benzylpenicillin is hydrolyzed into penicillin G once it is released from the injection site. Penicillin G attaches to the penicillin-binding proteins on bacterial cell wall and inhibit the transpeptidation enzyme that crosslinks the peptide chains attached to the backbone of the peptidoglycan. The final bactericidal event involves the inactivation of an inhibitor of autolytic enzymes in the cell wall, leading to lysis of the bacterium.
- Primary indication
- For the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria.Curator reviewed · 25 structured indications
- Formula / weight
- C29H38N4O6S · 570.71 g/mol (avg)
- First approval
- Canada, 1951 · United States, 1948
- Also known as
- Penicillin G procaine · procaine penicillin
- Brand names
Resolves to
WHRVRSCEWKLAHX-LQDWTQKMSA-NSMILESCCN(CC)CCOC(=O)C1=CC=C(N)C=C1.[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)CC1=CC=CC=C1)C(O)=OWhat you can answer from here — as of September 11, 2026
Which other approved drugs treat the same conditions as Procaine benzylpenicillin, and which companies have late-stage candidates in those indications?
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