Demeclocycline is a tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections. A tetracycline analog having a 7-chloro and a 6-methyl.
- Mechanism
- Curator reviewed
Demeclocycline inhibits cell growth by inhibiting translation. It binds (reversibly) to the 30S and 50S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, which impairs protein synthesis by bacteria. The binding is reversible in nature. The use in SIADH actually relies on a side-effect of tetracycline antibiotics; many may cause diabetes insipidus (dehydration due to the inability to concentrate urine). It is not completely understood why demeclocycline impairs the action of antidiuretic hormone, but it is thought that it blocks the binding of the hormone to its receptor.
- Primary indication
- Used primarily to treat Lyme disease, acne, and bronchitis.Curator reviewed · 26 structured indications
- Formula / weight
- C21H21ClN2O8 · 464.853 g/mol (avg)
- First approval
- Canada, 2003 · United States, 2004
- Also known as
- Demethylchlortetracyclin · Demethylchlortetracycline · DMCT · DMCTC
Resolves to
FMTDIUIBLCQGJB-SEYHBJAFSA-NSMILES[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)C1=C([C@H]2O)C(Cl)=CC=C1OWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Demeclocycline, and which of those have an active Phase 3 trial?
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