Methemoglobinemia (DBCOND0001602)

Identifiers

Synonyms

Methaemoglobinaemia / Methemoglobinemia, unspecified / Methaemoglobinaemia NOS / Methemoglobinemia (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Methylene blue	An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia.	Guanylate cyclase soluble subunit alpha-2target Nitric oxide synthase 1target UDP-glucuronosyltransferase 1A4enzyme UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Albumincarrier ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 2transporter Multidrug and toxin extrusion protein 2transporter Multidrug and toxin extrusion protein 1transporter Flavin reductase (NADPH)enzyme Cytochrome P450 2D6enzyme
Methylthioninium	The phenothiazine cation in methylene blue commonly used to treat methemoglobinemia.	Acetylcholinesterasetarget Transcriptional regulatortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01766999	Methemoglobinemia After Liposuction - Diagnostic by Pulse Oximetry and Blood Gas Analysis.	No drug interventions	Not Available	Not Available	completed
NCT02493283	Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration	Dapsone	basic_science	1	completed
NCT06309641	Methemoglobinemia Following Intravenous Iron Treatment	No drug interventions	Not Available	Not Available	recruiting
NCT03542760	Acquired Methemoglobinemia Observational Registry	Methylene blue	Not Available	Not Available	completed
NCT00993694	Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone	Dapsone	Not Available	Not Available	completed
NCT01402869	Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics	Epinephrine Lidocaine Prilocaine	Not Available	Not Available	completed
NCT02478281	Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults	Methylene blue	treatment	1	completed
NCT00960050	Methemoglobinemia in Patients With Childhood Hematologic Cancer or Aplastic Anemia Treated With Dapsone	No drug interventions	Not Available	1	unknown_status