Gonadotrophin releasing hormone deficiency (DBCOND0009162)

Identifiers

Synonyms

LHRH deficiency / GnRH Deficiency / Gonadotropin releasing factor deficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fluoxymesterone	A synthetic androgenic anabolic steroid that used in the treatment of hypogonadism and delayed puberty in males, as well as breast neoplasms in women.	Sex hormone-binding globulincarrier Estrogen receptortarget Androgen receptortarget Glucocorticoid receptortarget 11-beta-hydroxysteroid dehydrogenase type 2target
Testosterone	A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.	Androgen receptortarget Cytochrome P450 3A4enzyme Aromataseenzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic anion transporter 3transporter Solute carrier family 22 member 7transporter Hepatic sodium/bile acid cotransportertransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme Estrogen receptortarget Mineralocorticoid receptortarget Solute carrier organic anion transporter family member 1B3transporter
Testosterone cypionate	An androgen used to treat low or absent testosterone.	Androgen receptortarget Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Solute carrier family 22 member 7transporter ATP-dependent translocase ABCB1transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 3transporter Solute carrier family 22 member 4transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme Estrogen receptortarget Mineralocorticoid receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aromataseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00494169	Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	No drug interventions	Not Available	Not Available	completed
NCT00914823	Kisspeptin Administration in the Adult	Gonadorelin Kisspeptin	other	1	completed
NCT00493961	Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism	Gonadorelin	other	1	completed
NCT00392756	Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)	Gonadorelin	other	1	completed
NCT01438034	Kisspeptin in the Evaluation of Delayed Puberty	Gonadorelin Kisspeptin	other	1	completed