Testosterone cypionate is an androgen used to treat low or absent testosterone. Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester.
- Mechanism
- Curator reviewed · 1 reference
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5-alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-alpha-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
- Primary indication
- Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone.Curator reviewed · 10 structured indications
- Formula / weight
- C27H40O3 · 412.614 g/mol (avg)
- First approval
- Canada, 2003 · United States, 1979
- Also known as
- Testosterone cipionate · Testosterone cyclopentanepropionate · Testosterone cyclopentylpropionate
- Brand names
Resolves to
HPFVBGJFAYZEBE-ZLQWOROUSA-NSMILES[H][C@@]12CC[C@H](OC(=O)CCC3CCCC3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Testosterone cypionate, and which of those have an active Phase 3 trial?
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