Cholestatic pruritus (DBCOND0013142)

Identifiers

Synonyms

Cholestatic pruritis / Cholestatic pruritus (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Maralixibat	An ileal bile acid transporter inhibitor indicated to treat cholestatic pruritus in patients with Alagille syndrome.	Ileal sodium/bile acid cotransportertarget Solute carrier organic anion transporter family member 2B1transporter Cytochrome P450 3A4enzyme Hepatic sodium/bile acid cotransportertarget
Naltrexone	A narcotic antagonist used in opioid overdose.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Delta-type opioid receptortarget UDP-glucuronosyltransferase 1A1enzyme Sigma non-opioid intracellular receptor 1target
Odevixibat	An ileal sodium/bile acid cotransporter inhibitor indicated in the treatment of pruritus in patients with progressive familial intrahepatic cholestasis.	Ileal sodium/bile acid cotransportertarget ATP-dependent translocase ABCB1transporter
Ondansetron	A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.	5-hydroxytryptamine receptor 3Atarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme 5-hydroxytryptamine receptor 4target 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Btarget Mu-type opioid receptortarget Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme
Rifampin	An antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.	Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 5transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 2B1transporter Bile salt export pumptransporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 7transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 6transporter Organic anion transporter 3transporter UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 3A5enzyme Albumincarrier alpha1-acid glycoproteincarrier DNA-directed RNA polymerase subunit betatarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03995212	Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus	Difelikefalin	treatment	2	terminated