Angioedema (DBCOND0013604)

Identifiers

Synonyms

Angioedema reactions / Angio edema / Angioedemas / Angioneurotic edema / Angioedema (morphologic abnormality) / Angioneurotic oedema / Oedema angioneurotic / Quincke's edema / Angioedema (disorder) / Edema angioneurotic / Angioedema and urticaria / Angio-edema / Oedema Quincke's / Quincke's oedema / Giant urticaria / Edema Quincke's / Urticaria giant / Giant urticaria (disorder) / Giant hives / Hives giant

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Carbinoxamine	A first generation antihistamine used to treat allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, allergic reactions, and mild allergic reactions.	Histamine H1 receptortarget alpha1-acid glycoproteincarrier
Clemastine	An antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme
Dexchlorpheniramine maleate	A first generation antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema.	Cytochrome P450 2D6enzyme Histamine H1 receptortarget Solute carrier family 22 member 1carrier Solute carrier family 22 member 2carrier Cytochrome P450 3A4enzyme
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Pheniramine	An antihistamine used to treat allergic rhinitis and pruritus.	Histamine H1 receptortarget Nuclear receptor subfamily 1 group I member 3target Histamine H4 receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03029728	Biomarker for Hereditary AngioEdema Disease	No drug interventions	Not Available	Not Available	completed
NCT04963634	Research of Biomarkers Associated With the Diagnosis and Severity of Bradykinin Angioedema	No drug interventions	Not Available	Not Available	recruiting
NCT03917680	Evaluation of New Markers in Type 3 Angioedema	No drug interventions	diagnostic	Not Available	completed
NCT05936567	Study Evaluating the Efficacy and Safety of Povorcitinib in Adults With Chronic Spontaneous Urticaria	Povorcitinib	treatment	2	recruiting
NCT00125151	C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) Angioedema	Human C1-esterase inhibitor	treatment	3	completed
NCT06210698	Angioedema Biomarker Research Study	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04206605	A Study of Lanadelumab in Teenagers and Adults to Prevent Acute Attacks of Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH)	Lanadelumab	treatment	3	completed
NCT01154361	AMelioration of Angiotensin Converting Enzyme Inhibitor Induced Angioedema Study	Cortisone Icatibant	treatment	2	completed
NCT04583007	Expanded Access for the Prevention of Acute Attacks of 1) Hereditary Angioedema (HAE) in Children and 2) Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH) in Teenagers and Adults	Lanadelumab	Not Available	Not Available	no_longer_available
NCT01036659	Evaluation of Ecallantide for the Acute Treatment of Angiotensin Converting Enzyme Inhibitor Induced Angioedema	Bradykinin Ecallantide	treatment	2	unknown_status
NCT02833675	Determination of Specific Biomarkers of Angioneurotic Crisis	No drug interventions	Not Available	Not Available	completed
NCT04334031	Deployment o the Multidisciplinary Prospective Cohort Imminent	No drug interventions	other	Not Available	recruiting
NCT03240991	Study of Clinical, Biological Characteristics and Quality of Life of Patients With Hereditary or Acquired Non Drug-induced Bradykinin-mediated Angioedema, Monitored in Besançon's Partner Site Reference Center for Studies of Kinin-mediated Angioedema (CREAK)	No drug interventions	Not Available	Not Available	completed
NCT04597944	Lanadelumab in Bradykinin Angioedema	No drug interventions	Not Available	Not Available	recruiting
NCT01723072	Impact of Omalizumab on Quality of Life Measures and Angioedema Occurrence in Patients With CSU Refractory to Therapy	Omalizumab	treatment	3	completed
NCT00876369	Vitamin D Levels in Subjects With Chronic Urticaria and Angioedema	No drug interventions	Not Available	Not Available	completed
NCT04444895	A Study of Long-Term Safety and Efficacy of Lanadelumab for Prevention of Acute Attacks of Non-histaminergic Angioedema With Normal C1-Inhibitor	Lanadelumab	treatment	3	completed
NCT01371877	The Role of Vitamin D in Chronic Urticaria and Angioedema Treatment	Cholecalciferol	treatment	Not Available	completed
NCT06096077	Evaluation of Tranexamic Acid for Angiotensin-converting Enzyme Inhibitor-induced Angioedema in the Emergency Department	No drug interventions	Not Available	Not Available	completed
NCT04128371	Mepolizumab in Episodic Angioedema With Eosinophilia	Mepolizumab	treatment	2	terminated
NCT00125541	C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) Angioedema	Human C1-esterase inhibitor	prevention	2 / 3	completed
NCT05578417	A Study to Review the Treatment and Outcomes of Teenagers and Adults With Non-histaminergic Angioedema With Normal C1 Inhibitor in Canada	No drug interventions	Not Available	Not Available	completed
NCT00163839	The Efficacy of a Pseudoallergen-Free Diet in the Treatment of Chronic Idiopathic Urticaria and/or Angioedema	No drug interventions	treatment	Not Available	unknown_status
NCT00004694	Study of Heparin Prophylaxis of Hereditary Angioedema Exacerbations	Heparin	treatment	Not Available	completed
NCT00890162	A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	Epinephrine Omalizumab	treatment	2	completed
NCT00385372	Significance of an Elimination and Provocation Diet in Patients With Chronic Urticaria	No drug interventions	Not Available	Not Available	completed
NCT03845946	CLOUD-R HAE REGISTRY	No drug interventions	Not Available	Not Available	recruiting
NCT00097695	Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema	Icatibant L-Acetylleucine	treatment	3	completed