Clemastine

DB00283ApprovedInvestigationalSmall moleculeHistamine Antagonists

Clemastine is an antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis. An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus.

Chemical structure of Clemastine
Mechanism
Curator reviewed
Primary indication
For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation.Curator reviewed · 6 structured indications
Formula / weight
C21H26ClNO · 343.89 g/mol (avg)
First approval
Canada, 1992 · United States, 1992
Code names
HS-592
Brand names
  • Clemsza
  • Wal-hist 12 Hr Relief

Resolves to

Compound
UNII95QN29S1IDCAS15686-51-8ChEMBLCHEMBL1626ChEBI3738PubChem26987KEGGD03535
Clinical / RWD
RxNorm2578ATCD04AA14ATCR06AA04ATCR06AA54PharmGKBPA164776997
Structure
InChIKeyYNNUSGIPVFPVBX-NHCUHLMSSA-NSMILESCN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Targets
P35367HRH1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
1,069Drug interactionsStructured to mechanism, not free text
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23Clinical trialsPhase, status and sponsor resolved per trial
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6Structured indicationsCondition, population, route and combination as fields, not prose
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3ContraindicationsEach with its own population and attribute set
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55Marketed productsAcross 6 countries and 31 labellers
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3ATC codesIncluding every combination product, plus 18 drug categories
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15+ReferencesStructured and connected to the statements they support
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